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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems

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Fonseca-Santos, Bruno [1] ; Chorilli, Marlus [1]
Total Authors: 2
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, BR-14801903 Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: International Journal of Pharmaceutics; v. 589, NOV 15 2020.
Web of Science Citations: 2

Neurological disorders have been growing in recent years and are highly prevalent globally. Resveratrol (RES) is a natural product from plant sources such as grape skins. This compound has shown biological activity in many diseases, in particular, those that act on the central nervous system. The mechanism of action and the key points in neurological disorders were described and show the targeted mechanism of action. Due to the insolubility of this compound; the use of nanotechnology-based systems has been proposed for the incorporation of RES and RES-loaded nanocarriers have been designed for intranasal administration, oral or parenteral routes to deliver it to the brain. In general, these nanosystems have shown to be effective in many studies, pharmacological and pharmacokinetic assays, as well as some cell studies. The outcomes show that RES has been reported in human clinical trials for some neurological diseases, although no studies were performed in humans using nanocarriers, animal and/or cellular models have been reported to show good results regarding therapeutics on neurological diseases. Thus, the use of this nutraceutical has shown true for neurological diseases and its loading into nanocarriers displaying good results on the stability, delivery and targeting to the brain. (AU)

FAPESP's process: 14/24180-0 - Liquid crystalline systems as potential strategy ofr incorporation of trans-resveratrol: development, physicochemical characterization and in vitro and in vivo biological assays
Grantee:Marlus Chorilli
Support type: Regular Research Grants
FAPESP's process: 12/19568-4 - Evaluation of the potential of nanostructured lipid systems for cutaneous administration of trans-resveratrol
Grantee:Marlus Chorilli
Support type: Regular Research Grants
FAPESP's process: 15/05394-2 - Evaluating the potential of nanostructured surfactant-based systems to intranasal administration of trans-resveratrol in the optimization of Alzheimer's disease therapy
Grantee:Bruno da Fonseca dos Santos
Support type: Scholarships in Brazil - Doctorate