Probiotic supplementation in marathonists and its impact on lymphocyte population and function after a marathon: a randomized placebo-controlled double-blind study

Autor(es):Mostrar menos -

Batatinha, Helena ^{[1, 2]} ; Tavares-Silva, Edgar ^[3] ; Leite, Geovana S. F. ^[4] ; Resende, Ayane S. ^[4] ; Albuquerque, Jose A. T. ^[5] ; Arslanian, Christina ^[5] ; Fock, Ricardo A. ^[6] ; Lancha, Jr., Antonio H. ^[4] ; Lira, Fabio S. ^[7] ; Krueger, Karsten ^[8] ; Thomatieli-Santos, Ronaldo ^{[9, 3]} ; Rosa-Neto, Jose C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Immunometab Res Grp, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Dept Cell & Dev Biol, 1524 Prof Lineu Prestes Ave, BR-05508000 Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Programa Posgrad Psicobiol, Santos, SP - Brazil

^[4] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Appl Nutr & Metab, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

^[7] Univ Estadual Paulista UNESP, Sch Technol & Sci, Dept Phys Educ, Postgrad Program Movement Sci, Exercise & Immunome, Presidente Prudente - Brazil

^[8] Justus Liebig Univ Giessen, Dept Exercise Physiol & Sports Therapy, Giessen - Germany

^[9] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 10, n. 1 NOV 2 2020.
• Citações Web of Science: 0

Resumo

Probiotic supplementation arises as playing an immune-stimulatory role. High-intensity and -volume exercise can inhibit immune cell function, which threatens athletic performance and recovery. We hypothesized that 30 days of probiotic supplementation could stabilize the immune system of athletes preventing immune suppression after a marathon race. Twenty-seven male marathonists were double-blinded randomly into probiotic (Bifidobacterium-animalis-subsp.-Lactis (10x10(9)) and Lactobacillus-Acidophilus (10x10(9))+5 g of maltodextrin) and placebo (5 g of maltodextrin) group. They received 30 sachets and supplemented 1 portion/day during 30 days before the race. Blood were collected 30 days before (rest), 1 day before (pre), 1 h after (post) and 5 days after the race (recovery). Both chronic and acute exercise modulated a different T lymphocyte population (CD3(+)CD4(-)CD8(-) T-cells), increasing pre-race, decreasing post and returning to rest values at the recovery. The total number of CD8 T cell and the memory subsets statistically decreased only in the placebo group post-race. Pro-inflammatory cytokine production by stimulated lymphocytes decreased in the probiotic group after the supplementation period. 30 days of probiotic supplementation maintained CD8 T cell and effector memory cell population and played an immunomodulatory role in stimulated lymphocytes. Both, training and marathon modulated a non-classical lymphocyte population regardless of probiotic supplementation. (AU)

• Processo FAPESP: 19/09854-9 - O efeito da doxorrubicina sobre o tecido adiposo: elucidando o papel da família dos PPARs
• Beneficiário: José Cesar Rosa Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/10561-8 - Efeitos da suplementação de probióticos na modulação da microbiota oral e por consequência nas infecções do trato respiratório superior em corredores de longa distância.
• Beneficiário: Helena Angélica Pereira Batatinha
• Modalidade de apoio: Bolsas no Brasil - Doutorado