| Texto completo | |
| Autor(es): |
Fernandes, Carolina C.
[1]
;
Lanz, Bernard
[1]
;
Chen, Chen
[1]
;
Morris, Peter G.
[1]
;
Salmon, Carlos G.
[1, 2]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Nottingham NG7 2RD, Notts - England
[2] Univ Sao Paulo, Dept Phys, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NMR in Biomedicine; v. 34, n. 2 NOV 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
The present work aims to show the applicability of an analytical model for the optimisation of the STEAM sequence timing parameters for lactate detection at ultra high-field. The effects of the chemical shift displacement artefact on the J-modulated signal for a weakly-coupled spin system were considered in the three applied directions of field gradients and the product operator formalism was used to obtain expressions for the signal modulation in each compartment of the excited volume. The validity of this model was demonstrated experimentally at 7 T in a phantom and acquisitions with optimised parameters were performed on a healthy volunteer. The spectra acquired with TE = 144 ms with the optimised mixing time and TE = 288 ms showed easily detectable lactate peaks in the normal human brain. Additionally, the acquisition with the longer TE resulted in a spectrum with less lipid/macromolecular contamination. The simulations shown here demonstrated that the proposed analytical model is suitable for correctly predicting the resulting lactate signal. With the optimised parameters, it was possible to use a simple sequence with sufficient signal-to-noise ratio to reliably distinguish lactate from overlapping resonances in a healthy brain. (AU) | |
| Processo FAPESP: | 13/19340-6 - Conectividade metabólica cerebral usando espectroscopia de ressonância magnética de hidrogênio |
| Beneficiário: | Carlos Ernesto Garrido Salmon |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |