Chronic kidney failure following lancehead bite envenoming: a clinical report from the Amazon region

Autor(es)

Manuela B. Pucca ^[1] ; Michelle V. S. Franco ^[2] ; Jilvando M. Medeiros ^[3] ; Isadora S. Oliveira ^[4] ; Shirin Ahmadi ^[5] ; Felipe A. Cerni ^[6] ; Umberto Zottich ^[7] ; Bruna K. Bassoli ^[8] ; Wuelton M. Monteiro ; Andreas H. Laustsen ^[10]

Afiliação do(s) autor(es)

^[1] Federal University of Roraima. Medical School - Brasil

^[2] Federal University of Roraima. Medical School - Brasil

^[3] Federal University of Roraima. Medical School - Brasil

^[4] University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of BioMolecular Sciences - Brasil

^[5] Technical University of Denmark. Department of Biotechnology and Biomedicine - Dinamarca

^[6] University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of BioMolecular Sciences - Brasil

^[7] Federal University of Roraima. Medical School - Brasil

^[8] Federal University of Roraima. Medical School - Brasil

^[10] Technical University of Denmark. Department of Biotechnology and Biomedicine - Dinamarca

• Tipo de documento: Artigo Científico
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 26, 2020-12-14.

Resumo

Abstract Background: Snakebite envenoming can be a life-threatening condition, for which emergency care is essential. The Bothrops (lancehead) genus is responsible for most snakebite-related deaths and permanent loss of function in human victims in Latin America. Bothrops spp. venom is a complex mixture of different proteins that are known to cause local necrosis, coagulopathy, and acute kidney injury. However, the long-term effects of these viper envenomings have remained largely understudied. Case presentation: Here, we present a case report of a 46-years old female patient from Las Claritas, Venezuela, who was envenomed by a snake from the Bothrops genus. The patient was followed for a 10-year period, during which she presented oliguric renal failure, culminating in kidney failure 60 months after the envenoming. Conclusion: In Latin America, especially in Brazil, where there is a high prevalence of Bothrops envenoming, it may be relevant to establish long-term outpatient programs. This would reduce late adverse events, such as chronic kidney disease, and optimize public financial resources by avoiding hemodialysis and consequently kidney transplantation. (AU)

• Processo FAPESP: 17/03580-9 - Avaliação bioquímica, estrutural e funcional de uma fosfodiesterase da peçonha de Crotalus durissus collilineatus
• Beneficiário: Isadora Sousa de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/14035-1 - Melhoramento de fragmentos de anticorpos humanos (scFVs) específicos para peçonhas animais
• Beneficiário: Felipe Augusto Cerni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado