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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chronic kidney failure following lancehead bite envenoming: a clinical report from the Amazon region

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Author(s):
Manuela B. Pucca [1] ; Michelle V. S. Franco [2] ; Jilvando M. Medeiros [3] ; Isadora S. Oliveira [4] ; Shirin Ahmadi [5] ; Felipe A. Cerni [6] ; Umberto Zottich [7] ; Bruna K. Bassoli [8] ; Wuelton M. Monteiro ; Andreas H. Laustsen [10]
Total Authors: 10
Affiliation:
[1] Federal University of Roraima. Medical School - Brasil
[2] Federal University of Roraima. Medical School - Brasil
[3] Federal University of Roraima. Medical School - Brasil
[4] University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of BioMolecular Sciences - Brasil
[5] Technical University of Denmark. Department of Biotechnology and Biomedicine - Dinamarca
[6] University of São Paulo. School of Pharmaceutical Sciences of Ribeirão Preto. Department of BioMolecular Sciences - Brasil
[7] Federal University of Roraima. Medical School - Brasil
[8] Federal University of Roraima. Medical School - Brasil
[10] Technical University of Denmark. Department of Biotechnology and Biomedicine - Dinamarca
Total Affiliations: 10
Document type: Journal article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 26, 2020-12-14.
Abstract

Abstract Background: Snakebite envenoming can be a life-threatening condition, for which emergency care is essential. The Bothrops (lancehead) genus is responsible for most snakebite-related deaths and permanent loss of function in human victims in Latin America. Bothrops spp. venom is a complex mixture of different proteins that are known to cause local necrosis, coagulopathy, and acute kidney injury. However, the long-term effects of these viper envenomings have remained largely understudied. Case presentation: Here, we present a case report of a 46-years old female patient from Las Claritas, Venezuela, who was envenomed by a snake from the Bothrops genus. The patient was followed for a 10-year period, during which she presented oliguric renal failure, culminating in kidney failure 60 months after the envenoming. Conclusion: In Latin America, especially in Brazil, where there is a high prevalence of Bothrops envenoming, it may be relevant to establish long-term outpatient programs. This would reduce late adverse events, such as chronic kidney disease, and optimize public financial resources by avoiding hemodialysis and consequently kidney transplantation. (AU)

FAPESP's process: 17/03580-9 - Biochemical, structural and functional evaluation of a phosphodiesterase from Crotalus durissus collilineatus venom
Grantee:Isadora Sousa de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/14035-1 - Improving of human fragment antibodies (scFvs) specific for animals' venoms
Grantee:Felipe Augusto Cerni
Support Opportunities: Scholarships in Brazil - Post-Doctoral