Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition

Autor(es):Mostrar menos -

Alcantara Santos, Sergio Alexandre ^[1] ; Lima Camargo, Ana Carolina ^[1] ; Constantino, Flavia Bessi ^[1] ; Colombelli, Ketlin Thassiani ^[1] ; Frediani Portela, Luiz Marcos ^[1] ; Fioretto, Matheus Naia ^[1] ; Souza Vieira, Jose Cavalcante ^[2] ; Padilha, Pedro Magalhaes ^[2] ; de Oliveira, Mateus Betta ^[1] ; Felisbino, Sergio Luis ^[1] ; Carvalho, Robson Francisco ^[1] ; Justulin, Luis Antonio ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Struct & Funct Biol, BR-18618689 Botucatu, SP - Brazil

^[2] Sao Paulo State Univ Unesp, Inst Biosci, Dept Chem & Biol Sci, BR-18618689 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AGING-US; v. 12, n. 20, p. 19954-19978, OCT 31 2020.
• Citações Web of Science: 0

Resumo

The developmental origins of health and disease concept links adult diseases with early-life exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition may lead to an increased incidence of type 2 diabetes, obesity, and cardiovascular diseases. Maternal malnutrition (MM) has also been associated with prostate carcinogenesis. However, the molecular mechanisms associated with this condition remain poorly understood. Using a proteomic analysis, we demonstrated that MM changed the levels of proteins associated with growth factors, estrogen signaling, detoxification, and energy metabolism in the prostate of both young and old rats. These animals also showed increased levels of molecular markers of endoplasmic reticulum function and histones. We further performed an in silico analysis that identified commonly deregulated proteins in the ventral prostate of old rats submitted to MM with a mouse model and patients with prostate cancer. In conclusion, our results demonstrated that estrogenic signaling pathways, endoplasmic reticulum functions, energy metabolism, and molecular sensors of protein folding and Ca2+ homeostasis, besides histone, and RAS-GTPase family appear to be involved in this process. Knowledge of these factors may raise discussions regarding the role of maternal dietary intervention as a public policy for the lifelong prevention of chronic diseases. (AU)

• Processo FAPESP: 17/08715-0 - Análise integrativa do transcriptoma e proteômica da próstata ventral da prole de ratos submetidos à restrição protéica materna
• Beneficiário: Ana Carolina Lima Camargo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/01063-7 - Análises globais integrativas da próstata ventral de ratos submetidos a restrição protéica materna e suas repercussões com o envelhecimento
• Beneficiário: Luis Antonio Justulin Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/08531-8 - Impacto da restrição proteica gestacional e lactacional sobre a próstata de ratos: relação entre a via de sinalização da Insulina/IGF, desenvolvimento e envelhecimento
• Beneficiário: Sérgio Alexandre Alcantara dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado