| Texto completo | |
| Autor(es): |
Fernandes, Edgar Ruz
[1]
;
Barbosa, Marcela Luize
[1]
;
Amaral, Marcelo Pires
[1]
;
Apostolico, Juliana de Souza
[1]
;
Sulczewski, Fernando Bandeira
[2]
;
Tufik, Sergio
[3]
;
Andersen, Monica Levy
[3]
;
Boscardin, Silvia Beatriz
[2, 4]
;
Keller, Alexandre Castro
[1]
;
Rosa, Daniela Santoro
[4, 1]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Fed Univ Sao Paulo UNIFESP EPM, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
[3] Fed Univ Sao Paulo UNIFESP EPM, Dept Psychobiol, Sao Paulo - Brazil
[4] Inst Invest Immunol Iii INCT, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ISCIENCE; v. 23, n. 10 OCT 23 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Although the influence of sleep quality on the immune system is well documented, the mechanisms behind its impact on natural host immunity remain unclear. Meanwhile, it has been suggested that neuroimmune interactions play an important role in this phenomenon. To evaluate the impact of stress-induced sleep disturbance on host immunity, we used a murine model of rapid eye movement sleep deprivation (RSD) integrated with a model of malaria blood-stage infection. We demonstrate that sleep disturbance compromises the differentiation of T follicular helper cells, increasing host susceptibility to the parasite. Chemical inhibition of glucocorticoid (Glcs) synthesis showed that abnormal Glcs production compromised the transcription of Tfh-associated genes resulting in impaired germinal center formation and humoral immune response. Our data demonstrate that RSD-induced abnormal activation of the hypothalamic-pituitary-adrenal axis drives host susceptibility to infection. Understanding the impact of sleep quality in natural resistance to infection may provide insights for disease management. (AU) | |
| Processo FAPESP: | 19/11490-5 - Estudo sobre a influência do sistema nervoso simpático na atividade biológica dos linfócitos T invariantes Natural Killer |
| Beneficiário: | Alexandre de Castro Keller |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/17471-7 - Antigenicidade e imunogenicidade de proteínas recombinantes do envelope viral do Zika vírus |
| Beneficiário: | Daniela Santoro Rosa |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |