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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity

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Author(s):
Fernandes, Edgar Ruz [1] ; Barbosa, Marcela Luize [1] ; Amaral, Marcelo Pires [1] ; Apostolico, Juliana de Souza [1] ; Sulczewski, Fernando Bandeira [2] ; Tufik, Sergio [3] ; Andersen, Monica Levy [3] ; Boscardin, Silvia Beatriz [2, 4] ; Keller, Alexandre Castro [1] ; Rosa, Daniela Santoro [4, 1]
Total Authors: 10
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP EPM, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
[3] Fed Univ Sao Paulo UNIFESP EPM, Dept Psychobiol, Sao Paulo - Brazil
[4] Inst Invest Immunol Iii INCT, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ISCIENCE; v. 23, n. 10 OCT 23 2020.
Web of Science Citations: 0
Abstract

Although the influence of sleep quality on the immune system is well documented, the mechanisms behind its impact on natural host immunity remain unclear. Meanwhile, it has been suggested that neuroimmune interactions play an important role in this phenomenon. To evaluate the impact of stress-induced sleep disturbance on host immunity, we used a murine model of rapid eye movement sleep deprivation (RSD) integrated with a model of malaria blood-stage infection. We demonstrate that sleep disturbance compromises the differentiation of T follicular helper cells, increasing host susceptibility to the parasite. Chemical inhibition of glucocorticoid (Glcs) synthesis showed that abnormal Glcs production compromised the transcription of Tfh-associated genes resulting in impaired germinal center formation and humoral immune response. Our data demonstrate that RSD-induced abnormal activation of the hypothalamic-pituitary-adrenal axis drives host susceptibility to infection. Understanding the impact of sleep quality in natural resistance to infection may provide insights for disease management. (AU)

FAPESP's process: 19/11490-5 - The role of the sympathetic nervous system on the biological activity of invariant natural killer T lymphocytes
Grantee:Alexandre de Castro Keller
Support type: Regular Research Grants
FAPESP's process: 17/17471-7 - Antigenicity and immunogenicity of Zika virus envelope recombinant proteins
Grantee:Daniela Santoro Rosa
Support type: Regular Research Grants