Unplanned absorption of sunscreen ingredients: Impact of formulation and evaluation methods

Autor(es)

Romanhole, Rodrigo Collina ^[1] ; Masquetti Fava, Ana Laura ^[1] ; Tundisi, Louise Lacalendola ^[2] ; de Macedo, Lucas Malvezzi ^[1] ; dos Santos, Erica Mendes ^[2] ; Ataide, Janaina Artem ^[2] ; Mazzola, Priscila Gava ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Med Sci, UNICAMP, Campinas - Brazil

^[2] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, Rua Candido Portinari 200, BR-13083871 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: International Journal of Pharmaceutics; v. 591, DEC 15 2020.
• Citações Web of Science: 0

Resumo

Permeation of sunscreens agents reduces its effectiveness and safety, leading to systemic circulation and causing unknown adverse effects. In order to maintain the sunscreen efficacy and safety, the filters must stay on the skin surface, with minimum penetration through dermis. Even facing the possibility of filters permeation, the use of sunscreen is important to avoid skin damage as erythema, free-radicals formation, skin ageing and skin cancer, caused by ultraviolet radiation. Aiming potential side effects caused by topical absorption of sunscreens, studies are carried to improve formulation characteristics and stability, reduce skin permeation and evaluate sun protections factor (SPF). Current assays to detect the permeation of sunscreens involve in vivo or in vitro studies, to simulate physiological conditions of use. The aim of this review is to revisit sunscreen skin permeation data over the last decade and the factors that can enhance skin permeation or improve the sunscreen efficacy. (AU)

• Processo FAPESP: 19/03394-6 - Avaliação do impacto de emulsionantes e emolientes na permeação de filtros solares in vitro e sua correlação com a eficácia
• Beneficiário: Ana Laura Masquetti Fava
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica