Unplanned absorption of sunscreen ingredients: Impact of formulation and evaluation methods

Author(s)

Romanhole, Rodrigo Collina ^[1] ; Masquetti Fava, Ana Laura ^[1] ; Tundisi, Louise Lacalendola ^[2] ; de Macedo, Lucas Malvezzi ^[1] ; dos Santos, Erica Mendes ^[2] ; Ataide, Janaina Artem ^[2] ; Mazzola, Priscila Gava ^[2]

Affiliation

^[1] Univ Estadual Campinas, Sch Med Sci, UNICAMP, Campinas - Brazil

^[2] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, Rua Candido Portinari 200, BR-13083871 Campinas, SP - Brazil

• Document type: Review article
• Source: International Journal of Pharmaceutics; v. 591, DEC 15 2020.
• Web of Science Citations: 0

Abstract

Permeation of sunscreens agents reduces its effectiveness and safety, leading to systemic circulation and causing unknown adverse effects. In order to maintain the sunscreen efficacy and safety, the filters must stay on the skin surface, with minimum penetration through dermis. Even facing the possibility of filters permeation, the use of sunscreen is important to avoid skin damage as erythema, free-radicals formation, skin ageing and skin cancer, caused by ultraviolet radiation. Aiming potential side effects caused by topical absorption of sunscreens, studies are carried to improve formulation characteristics and stability, reduce skin permeation and evaluate sun protections factor (SPF). Current assays to detect the permeation of sunscreens involve in vivo or in vitro studies, to simulate physiological conditions of use. The aim of this review is to revisit sunscreen skin permeation data over the last decade and the factors that can enhance skin permeation or improve the sunscreen efficacy. (AU)

• FAPESP's process: 19/03394-6 - Emulsifiers and emollients impact assessment in the permeation of sun filters and its correlation with the effectiveness
• Grantee: Ana Laura Masquetti Fava
• Support Opportunities: Scholarships in Brazil - Scientific Initiation