Unravelling neurological disorders through metallomics-based approaches

Autor(es)

de Jesus, Jemmyson Romario ^[1] ; Zezzi Arruda, Marco Aurelio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, POB 6154, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: METALLOMICS; v. 12, n. 12, p. 1878-1896, DEC 1 2020.
• Citações Web of Science: 0

Resumo

Understanding the biological process involving metals and biomolecules in the brain is essential for establishing the origin of neurological disorders, such as neurodegenerative and psychiatric diseases. From this perspective, this critical review presents recent advances in this topic, showing possible mechanisms involving the disruption of metal homeostasis and the pathogenesis of neurological disorders. We also discuss the main challenges observed in metallomics studies associated with neurological disorders, including those related to sample preparation and analyte quantification. Significance to metallomics Neurological disorders are pathological conditions in which the brain's biochemistry is affected, causing cell dysfunction and deficiencies. There is accumulated evidence that altered metal homeostasis may be related to the emergence and progression of neurological diseases. Therefore, examining the effects of metal ion binding on the aggregation pathways and dysregulation of metal homeostasis remains essential for understanding neurological disorders, such as neurodegenerative and psychiatric diseases. Then, this work presents a critical review of the advances in this topic, highlighting the fundamental role of metallomics strategies for these advances. (AU)

• Processo FAPESP: 20/02020-2 - Caracterização, determinação e quantificação de nanopartículas usando espectrometria de massa de plasma com plasma indutivamente acoplado e single-particle (sp-ICPMS)
• Beneficiário: Aline Martins de Andrade
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/25207-0 - Nanometalômica aplicada ao cultivo da soja para estudar os efeitos das nanopartículas relacionadas a metal
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/07384-7 - Bioimageamento elementar por meio da ablação a laser e espectrometria de massas com plasma indutivamente acoplado
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Regular