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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Unravelling neurological disorders through metallomics-based approaches

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Author(s):
de Jesus, Jemmyson Romario [1] ; Zezzi Arruda, Marco Aurelio [1]
Total Authors: 2
Affiliation:
[1] Univ Estadual Campinas, Inst Chem, POB 6154, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: METALLOMICS; v. 12, n. 12, p. 1878-1896, DEC 1 2020.
Web of Science Citations: 0
Abstract

Understanding the biological process involving metals and biomolecules in the brain is essential for establishing the origin of neurological disorders, such as neurodegenerative and psychiatric diseases. From this perspective, this critical review presents recent advances in this topic, showing possible mechanisms involving the disruption of metal homeostasis and the pathogenesis of neurological disorders. We also discuss the main challenges observed in metallomics studies associated with neurological disorders, including those related to sample preparation and analyte quantification. Significance to metallomics Neurological disorders are pathological conditions in which the brain's biochemistry is affected, causing cell dysfunction and deficiencies. There is accumulated evidence that altered metal homeostasis may be related to the emergence and progression of neurological diseases. Therefore, examining the effects of metal ion binding on the aggregation pathways and dysregulation of metal homeostasis remains essential for understanding neurological disorders, such as neurodegenerative and psychiatric diseases. Then, this work presents a critical review of the advances in this topic, highlighting the fundamental role of metallomics strategies for these advances. (AU)

FAPESP's process: 20/02020-2 - Characterization, determination and quantification of nanoparticles using single particle-Inductively Coupled Plasma Mass Spectrometry (sp-ICPMS)
Grantee:Aline Martins de Andrade
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/25207-0 - Nanometallomics applied to soybean cultivation for studying the effects of metal-related nanoparticles
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/07384-7 - Elementary bioimaging through laser ablation and inductively coupled plasma mass spectrometry
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Regular Research Grants