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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A multicenter comparative acute myeloid leukemia study: can we explain the differences in the outcomes in resource-constrained settings?

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Autor(es):
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Silveira, Douglas R. A. [1, 2, 3] ; Coelho-Silva, Juan L. [4] ; Silva, Wellington F. [5] ; Vallance, Grant [6] ; Pereira-Martins, Diego A. [4] ; Madeira, Maria I. A. [4] ; Figueredo-Pontes, Lorena L. [4] ; Velloso, Elvira D. R. P. [2, 3, 5] ; Simoes, Belinda P. [4] ; Peniket, Andy [6] ; Danby, Robert [6] ; Rego, Eduardo M. [2, 3, 5] ; Vyas, Paresh [6, 7] ; Traina, Fabiola [4] ; Bendit, Israel [2, 3] ; Quek, Lynn [8] ; Rocha, Vanderson [2, 3, 5, 6]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] AC Camargo Canc Ctr, Dept Hematol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Serv Hematol Transfus & Cell Therapy, Sao Paulo - Brazil
[3] Univ Sao Paulo, Med Sch, Lab Med Invest Pathogenesis & Directed Therapy On, Sao Paulo - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP, Dept Med Images Hematol & Clin Oncol, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Canc Inst Sao Paulo ICESP, Leukemia Unit, Med Sch, Sao Paulo, SP - Brazil
[6] Oxford Univ Hosp NHS Fdn Trust, Dept Haematol, Oxford - England
[7] Univ Oxford, Radcliffe Dept Med, Oxford Ctr Hematol, WIMM, MRC MHU, BRC Haematol Theme, Oxford Biomed Res Ctr, Oxford - England
[8] Kings Coll Hosp NHS Fdn Trust, Dept Haematol Med, London - England
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: Leukemia & Lymphoma; v. 62, n. 1, p. 147-157, JAN 2 2021.
Citações Web of Science: 0
Resumo

Outcomes in acute myeloid leukemia (AML) are dependent on patient- and disease-characteristics, treatment, and socioeconomic factors. AML outcomes between resource-constrained and developed countries have not been compared directly. We analyzed two cohorts: from Sao Paulo state, Brazil (USP,n = 312) and Oxford, United Kingdom (OUH,n = 158). USP cohort had inferior 5-year overall survival compared with OUH (29% vs. 49%, adjusted-p=.027). USP patients have higher early-mortality (23% vs. 6%p<.001) primarily due to multi-resistant Gram-negative bacterial and fungal infections. USP had higher 5-year cumulative incidence of relapse (60% vs. 50%,p=.0022), were less likely to undergo hematopoietic stem cell transplant (HSCT) (28% vs. 75%,p<.001) and waited longer for HSCT (median, 23.8 vs. 7.2 months,p<.001). Three-year survival in relapsed patients was worse in USP than OUH (10% vs. 39%,p<.001). Our study indicates that efforts to improve AML outcomes in Brazil should focus on infection prevention and control, and access to HSCT. (AU)

Processo FAPESP: 16/23191-4 - Investigação da Participação de IRS2 na patogênese de neoplasias mieloproliferativas JAK2V617F utilizando modelos murinos
Beneficiário:Juan Luiz Coelho da Silva
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/23117-1 - Avaliação da via TP53/TP73 na enxertia de células de leucemia promielocítica aguda em modelo de xenotransplante
Beneficiário:Diego Antonio Pereira Martins
Linha de fomento: Bolsas no Brasil - Doutorado