Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association-identified risk variants in a Southeastern Brazilian population

Autor(es)

Cirelli, Thamiris ^{[1, 2]} ; Nepomuceno, Rafael ^{[1, 2]} ; Goveia, Jessica Marina ^[2] ; Orrico, Silvana R. P. ^{[1, 3]} ; Cirelli, Joni A. ^[1] ; Theodoro, Leticia Helena ^[4] ; Barros, Silvana P. ^[5] ; Scarel-Caminaga, Raquel M. ^[2]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Morphol Genet Orthodont & Pediat Dent, Araraquara, SP - Brazil

^[3] Union Coll Great Lakes UNILAGO, Sao Jose Dos Campos, SP - Brazil

^[4] Sao Paulo State Univ UNESP, Sch Dent Aracatuba, Dept Surg & Integrated Clin, Aracatuba, SP - Brazil

^[5] Univ North Carolina Chapel Hill UNC, Sch Dent, Dept Comprehens Oral Hlth Periodontol, Chapel Hill, NC - USA

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 25, n. 6 JAN 2021.
• Citações Web of Science: 0

Resumo

Objective Genome-wide association studies (GWAS) and literature have identified polymorphisms in the KCNJ11, HNF1A, IRS1, TCF7L2, CDKAL1, CDKN2B, RPSAP52, GPR45 HHEX, IL18, and RUNX2 genes associated with type 2 diabetes mellitus (T2DM) and/or periodontitis (P) in diverse populations, and we sought to evaluate them as genetic risk variants for these diseases in the Brazilian population. Material and methods Periodontal, glycemic, and lipid data were obtained from 931 individuals divided into: control (n = 334), periodontitis (P; n = 358), and periodontitis associated with T2DM (P + T2DM; n = 239). After genotyping, associations between polymorphisms and pathologies were tested by multiple logistic and linear regressions, adjusting for age, sex, and smoking habits. Results Considering the studied subjects, the increased risk to develop periodontitis in the periodontitis P + T2DM group was found for HNF1A-rs7957197-TA, CDKAL1-rs7754840-CG, RPSAP52-rs1531343-GC, TCF7L2-rs7903146-TT, and CDKN2B-rs7018475-GG. The association of these genetic variants for TCF7L2 and CDKN2B was confirmed for female, never smokers, and poorly controlled P + T2DM. CDKN2B-rs7018475 was associated with worse glycemic condition and periodontal parameters. Conclusion These five reported genetic variants were associated in the studied Southeastern Brazilian population as genetic risk variants of periodontitis and T2DM associated to periodontitis as comorbidity. Gene-phenotype associations with sex and smoking habits and the CDKN2B-rs7018475 with the poor glycemic control and more severe periodontal conditions should be further investigated. (AU)

• Processo FAPESP: 18/26367-1 - Investigação da associação de polimorfismos no gene defensina beta1 (DEFB1)com suscetibilidade à doença periodontal crônica e diabetes mellitus tipo 2
• Beneficiário: Ana Cláudia dos Santos Rios
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/13295-1 - Investigação da associação de variações genéticas na suscetibilidade à doença periodontal crônica por meio de OpenArray®
• Beneficiário: Rafael Nepomuceno Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/18313-3 - Investigação da susceptibilidade de variações genéticas a Periodontite Crônica por OpenArray®: Bioestatística, Bioinformática e Análise Funcional
• Beneficiário: Rafael Nepomuceno Oliveira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 16/08070-6 - Investigação da suscetibilidade genética à periodontite crônica associada ao Diabetes mellitus tipo 2
• Beneficiário: Thamiris Cirelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/03753-8 - Investigação de potenciais marcadores genéticos da periodontite crônica associada ou não ao Diabetes Mellitus tipo 2 por meio da suscetibilidade genética e do perfil glicêmico e lipídico do paciente
• Beneficiário: Raquel Mantuaneli Scarel Caminaga
• Modalidade de apoio: Auxílio à Pesquisa - Regular