Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury

Autor(es)

Cermaria Soares da Silva, Beatriz Helena ^[1] ; Ariga, Suely Kubo ^[1] ; Barbeiro, Hermes Vieira ^[1] ; Volpini, Rildo Aparecido ^[2] ; Barbeiro, Denise Frediani ^[1] ; Seguro, Antonio Carlos ^[2] ; da Silva, Fabiano Pinheiro ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Emergencias Clin, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Lab Invest Med 12 LIM12, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF MEDICAL SCIENCES; v. 18, n. 4, p. 883-890, 2021.
• Citações Web of Science: 0

Resumo

Background: Cathelicidins are ancient and well-conserved antimicrobial peptides (AMPs) with intriguing immunomodulatory properties in both infectious and non-infectious inflammatory diseases. In addition to direct antimicrobial activity, cathelicidins also participate in several signaling pathways inducing both pro-inflammatory and anti-inflammatory effects. Acute kidney injury (AKI) is common in critically ill patients and is associated with high mortality and morbidity. Rhabdomyolysis is a major trigger of AKI. Objectives: Here, we investigated the role of cathelicidins in non-infectious Acute kidney Injury (AKI). Method: Using an experimental model of rhabdomyolysis, we induced AKI in wild-type and cathelicidin-related AMP knockout (CRAMP(-/-)) mice. Results: We previously demonstrated that CRAMP(-/-) mice, as opposed wild-type mice, are protected from AKI during sepsis induced by cecal ligation and puncture. Conversely, in the current study, we show that CRAMP(-/-) mice are more susceptible to the rhabdomyolysis model of AKI. A more in-depth investigation of wild-type and CRAMP(-/-) mice revealed important differences in the levels of several inflammatory mediators. Conclusion: Cathelicidins can induce a varied and even opposing repertoire of immune-inflammatory responses depending on the subjacent disease and the cellular context. (AU)

• Processo FAPESP: 18/06124-7 - Peptídeos Antimicrobianos: Mecanismos de ação e impacto em Terapia Intensiva
• Beneficiário: Fabiano Pinheiro da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular