| Full text | |
| Author(s): |
Cermaria Soares da Silva, Beatriz Helena
[1]
;
Ariga, Suely Kubo
[1]
;
Barbeiro, Hermes Vieira
[1]
;
Volpini, Rildo Aparecido
[2]
;
Barbeiro, Denise Frediani
[1]
;
Seguro, Antonio Carlos
[2]
;
da Silva, Fabiano Pinheiro
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Dept Emergencias Clin, Sao Paulo - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Lab Invest Med 12 LIM12, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES; v. 18, n. 4, p. 883-890, 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Cathelicidins are ancient and well-conserved antimicrobial peptides (AMPs) with intriguing immunomodulatory properties in both infectious and non-infectious inflammatory diseases. In addition to direct antimicrobial activity, cathelicidins also participate in several signaling pathways inducing both pro-inflammatory and anti-inflammatory effects. Acute kidney injury (AKI) is common in critically ill patients and is associated with high mortality and morbidity. Rhabdomyolysis is a major trigger of AKI. Objectives: Here, we investigated the role of cathelicidins in non-infectious Acute kidney Injury (AKI). Method: Using an experimental model of rhabdomyolysis, we induced AKI in wild-type and cathelicidin-related AMP knockout (CRAMP(-/-)) mice. Results: We previously demonstrated that CRAMP(-/-) mice, as opposed wild-type mice, are protected from AKI during sepsis induced by cecal ligation and puncture. Conversely, in the current study, we show that CRAMP(-/-) mice are more susceptible to the rhabdomyolysis model of AKI. A more in-depth investigation of wild-type and CRAMP(-/-) mice revealed important differences in the levels of several inflammatory mediators. Conclusion: Cathelicidins can induce a varied and even opposing repertoire of immune-inflammatory responses depending on the subjacent disease and the cellular context. (AU) | |
| FAPESP's process: | 18/06124-7 - Antimicrobial Peptides: Mechanisms of Action and Impact in Critical Care |
| Grantee: | Fabiano Pinheiro da Silva |
| Support Opportunities: | Regular Research Grants |