Standardization of a new non-invasive device for assessment of arterial stiffness in rats: Correlation with age-related arteries' structure

Autor(es)

Fabricio, Mayara F. ^{[1, 2]} ; Jordao, Maria T. ^[3] ; Miotto, Danyelle S. ^{[1, 2]} ; Ruiz, Thalles F. R. ^[4] ; Vicentini, Carlos A. ^[4] ; Lacchini, Silvia ^[5] ; Santos, Carlos Ferreira ^[6] ; Michelini, Lisete C. ^[3] ; Amaral, Sandra L. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Sch Sci, Dept Phys Educ, Bauru, SP - Brazil

^[2] UFSCar UNESP, Joint Grad Program Physiol Sci, PIPGCF, Sao Carlos, SP - Brazil

^[3] Univ Sao Paulo SP, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil

^[4] Sao Paulo State Univ UNESP, Sch Sci, Dept Biol Sci, Bauru, SP - Brazil

^[5] Univ Sao Paulo SP, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil

^[6] Univ Sao Paulo, Bauru Sch Dent, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: METHODSX; v. 7, 2020.
• Citações Web of Science: 2

Resumo

Pulse wave velocity (PWV) has become a gold standard index to quantify the stiffness of the aorta and is a predictor of cardiovascular events. A recent paper compared the pOpmetre (R), a device for measuring the fingertoe PWV, with other techniques and demonstrated its accuracy and validity. However, human devices do not allow the advancement of our knowledge on conditioning mechanisms. Based on its human validation, a new device, pOpet (R) 1.0 system was designed for estimation of PWV in small animals and this present study aimed to standardize the pOpet (R) 1.0 for estimation of arterial stiffness in rats, and to confirm its liability and stability as well as the reproducibility of assessments. Therefore several precautions were taken into consideration like as the correct position of the animal and photodiodes according to manufacturers' suggestions. Results indicated that estimation of PWV through the new pOpet (R) 1.0 device exhibits good internal consistency, stability and objectivity in all tests performed between days and evaluators. Importantly, data suggest for the first time that this new device is able to detect changes in arterial stiffness that are conditioned by age and pressure-related arterial remodeling. This new pOpet (R) device is able to detect changes in vessel structure. This new pOpet (R) device exhibits good internal consistency, stability and objectivity in all tests performed Correct position of the animal and photodiodes are crucial to obtain a very stable signal. (C) 2020 The Author(s). Published by Elsevier B.V. (AU)

• Processo FAPESP: 18/14544-6 - Barreira hematoencefálica: um novo paradigma no tratamento da hipertensão
• Beneficiário: Lisete Compagno Michelini
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/23229-6 - Efeitos do treinamento físico na hipertensão, enrijecimento arterial e atrofia muscular induzidos por dexametasona: papel do estresse oxidativo
• Beneficiário: Sandra Lia do Amaral Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/03965-2 - Papel do sistema renina-angiotensina em diferentes modelos inflamatórios orais: uma abordagem interdisciplinar experimental e clínica
• Beneficiário: Carlos Ferreira dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/00509-1 - Papel do treinamento físico no balanço autonômico, rigidez arterial e rarefação em ratos espontaneamente hipertensos tratados com dexametasona: contribuição dos microRNAs
• Beneficiário: Sandra Lia do Amaral Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular