Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Standardization of a new non-invasive device for assessment of arterial stiffness in rats: Correlation with age-related arteries' structure

Full text
Author(s):
Fabricio, Mayara F. [1, 2] ; Jordao, Maria T. [3] ; Miotto, Danyelle S. [1, 2] ; Ruiz, Thalles F. R. [4] ; Vicentini, Carlos A. [4] ; Lacchini, Silvia [5] ; Santos, Carlos Ferreira [6] ; Michelini, Lisete C. [3] ; Amaral, Sandra L. [1, 2]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ Unesp, Sch Sci, Dept Phys Educ, Bauru, SP - Brazil
[2] UFSCar UNESP, Joint Grad Program Physiol Sci, PIPGCF, Sao Carlos, SP - Brazil
[3] Univ Sao Paulo SP, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[4] Sao Paulo State Univ UNESP, Sch Sci, Dept Biol Sci, Bauru, SP - Brazil
[5] Univ Sao Paulo SP, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Bauru Sch Dent, Bauru, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: METHODSX; v. 7, 2020.
Web of Science Citations: 2
Abstract

Pulse wave velocity (PWV) has become a gold standard index to quantify the stiffness of the aorta and is a predictor of cardiovascular events. A recent paper compared the pOpmetre (R), a device for measuring the fingertoe PWV, with other techniques and demonstrated its accuracy and validity. However, human devices do not allow the advancement of our knowledge on conditioning mechanisms. Based on its human validation, a new device, pOpet (R) 1.0 system was designed for estimation of PWV in small animals and this present study aimed to standardize the pOpet (R) 1.0 for estimation of arterial stiffness in rats, and to confirm its liability and stability as well as the reproducibility of assessments. Therefore several precautions were taken into consideration like as the correct position of the animal and photodiodes according to manufacturers' suggestions. Results indicated that estimation of PWV through the new pOpet (R) 1.0 device exhibits good internal consistency, stability and objectivity in all tests performed between days and evaluators. Importantly, data suggest for the first time that this new device is able to detect changes in arterial stiffness that are conditioned by age and pressure-related arterial remodeling. This new pOpet (R) device is able to detect changes in vessel structure. This new pOpet (R) device exhibits good internal consistency, stability and objectivity in all tests performed Correct position of the animal and photodiodes are crucial to obtain a very stable signal. (C) 2020 The Author(s). Published by Elsevier B.V. (AU)

FAPESP's process: 18/14544-6 - Blood-brain barrier: a new paradigm in the treatment of hypertension
Grantee:Lisete Compagno Michelini
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/23229-6 - Physical training effects on hypertension, arterial stiffness and muscle atrophy induced by dexamethasone: role of oxidative stress
Grantee:Sandra Lia do Amaral Cardoso
Support Opportunities: Regular Research Grants
FAPESP's process: 15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach
Grantee:Carlos Ferreira dos Santos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/00509-1 - Role of physical training on autonomic balance, arterial stiffness and rarefaction in spontaneously hypertensive rats treated with dexamethasone: role of miRNA
Grantee:Sandra Lia do Amaral Cardoso
Support Opportunities: Regular Research Grants