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Sedentary behaviour and arterial dysfunction in chronic post-stroke subjects

Grant number: 17/13655-6
Support type:Regular Research Grants
Duration: March 01, 2018 - February 29, 2020
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Thiago Luiz de Russo
Grantee:Thiago Luiz de Russo
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):18/19434-4 - Sedentary behavior and arterial dysfunction in chronic post-stroke individuals, BP.TT


Post-stroke disability leads to a sedentary lifestyle, increasing the risk of developing a new cerebrovascular and/or cardiac events. Arterial dysfunction plays an important role in the pathophysiology of these events. Endothelial dysfunction, arterial stiffness and autonomic nervous system dysfunction are associated with increased risk of cardiovascular disease, morbidity and mortality. and there seems to be correlation among these variables. However, information about the impact of stroke on these variables and how they are affected by a sedendaty behavior in post-stroke patients is insufficient. Therefore, the purpose of this project is to characterize arterial function with sedentary time among hemiparetic patients after stroke in chronic stage of recovery. To do that, a cross-sectional study will be conducted with 30 patients in chronic phase of stroke (at least 6 months post-stroke) and 30 healhty subjects matched by age, sex, body mass index. The assessments will be carried out in 2 days with one week between each day. On the first day, the sensory-motor impairment of post-stroke patients will be assessed, and the 6-minute walk test and the 10-meter walk test will be performed. Finally, the accelerometer will be placed on the ankle of the volunteer who should use it uninterruptedly for 7 days. On the second day, the accelerometer will be removed, autonomic nervous system function, arterial stiffness and endothelial fuction will be evaluated. The data will be statistically analyzed with normality and homogeneity tests to define the use of parametric or non-parametric analysis. Independent Student's t-test or Mann-Whitney test will be used to compare the differences between groups, and Pearson's correlation coefficient or Spearman's correlation coeficiente will be used to correlate the data. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOREIRA DA SILVA, ERIKA SHIRLEY; SANTOS, GABRIELA LOPES; CATAI, APARECIDA MARIA; BORSTAD, ALEXANDRA; DUARTE FURTADO, NATALIA PEREIRA; VERZOLA ANICETO, ISABELA ARRUDA; RUSSO, THIAGO LUIZ. Effect of aerobic exercise prior to modified constraint-induced movement therapy outcomes in individuals with chronic hemiparesis: a study protocol for a randomized clinical trial. BMC Neurology, v. 19, n. 1 AUG 15 2019. Web of Science Citations: 1.
SILVA-COUTO, M. A.; SIQUEIRA, A. A. G.; SANTOS, GABRIELA L.; RUSSO, THAIGO L. Ankle torque steadiness and gait speed after a single session of robot therapy in individuals with chronic hemiparesis: a pilot study. Topics in Stroke Rehabilitation, AUG 2019. Web of Science Citations: 0.
ALCANTARA, CAROLINA CARMONA; BLANCO, JULIA; DE OLIVEIRA, LUCILENE MARIA; SAVIO RIBEIRO, PAULA FERNANDA; HERRERA, ESPERANZA; NAKAGAWA, THERESA HELISSA; REISMAN, DARCY S.; MICHAELSEN, STELLA MARIS; GARCIA, LUCCAS CAVALCANTI; RUSSO, THIAGO LUIZ. Cryotherapy reduces muscle hypertonia, but does not affect lower limb strength or gait kinematics post-stroke: a randomized controlled crossover study. Topics in Stroke Rehabilitation, v. 26, n. 4, p. 267-280, MAY 19 2019. Web of Science Citations: 0.
GARCIA, LUCCAS CAVALCANTI; ALCANTARA, CAROLINA CARMONA; SANTOS, GABRIELA LOPES; ALMEIDA MONCAO, JOAO VICTOR; RUSSO, THIAGO LUIZ. Cryotherapy Reduces Muscle Spasticity But Does Not Affect Proprioception in Ischemic Stroke A Randomized Sham-Controlled Crossover Study. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 98, n. 1, p. 51-57, JAN 2019. Web of Science Citations: 1.
ALCANTARA, CAROLINA C.; GARCIA-SALAZAR, LUISA F.; SILVA-COUTO, MARCELA A.; SANTOS, GABRIELA L.; REISMAN, DARCY S.; RUSSO, THIAGO L. Post-stroke BDNF Concentration Changes Following Physical Exercise: A Systematic Review. FRONTIERS IN NEUROLOGY, v. 9, AUG 28 2018. Web of Science Citations: 4.

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