Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characteriz...
| Grant number: | 17/13655-6 |
| Support type: | Regular Research Grants |
| Duration: | March 01, 2018 - February 29, 2020 |
| Field of knowledge: | Health Sciences - Physiotherapy and Occupational Therapy |
| Principal Investigator: | Thiago Luiz de Russo |
| Grantee: | Thiago Luiz de Russo |
| Home Institution: | Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil |
| Associated scholarship(s): | 18/19434-4 - Sedentary behavior and arterial dysfunction in chronic post-stroke individuals, BP.TT |
Abstract
Post-stroke disability leads to a sedentary lifestyle, increasing the risk of developing a new cerebrovascular and/or cardiac events. Arterial dysfunction plays an important role in the pathophysiology of these events. Endothelial dysfunction, arterial stiffness and autonomic nervous system dysfunction are associated with increased risk of cardiovascular disease, morbidity and mortality. and there seems to be correlation among these variables. However, information about the impact of stroke on these variables and how they are affected by a sedendaty behavior in post-stroke patients is insufficient. Therefore, the purpose of this project is to characterize arterial function with sedentary time among hemiparetic patients after stroke in chronic stage of recovery. To do that, a cross-sectional study will be conducted with 30 patients in chronic phase of stroke (at least 6 months post-stroke) and 30 healhty subjects matched by age, sex, body mass index. The assessments will be carried out in 2 days with one week between each day. On the first day, the sensory-motor impairment of post-stroke patients will be assessed, and the 6-minute walk test and the 10-meter walk test will be performed. Finally, the accelerometer will be placed on the ankle of the volunteer who should use it uninterruptedly for 7 days. On the second day, the accelerometer will be removed, autonomic nervous system function, arterial stiffness and endothelial fuction will be evaluated. The data will be statistically analyzed with normality and homogeneity tests to define the use of parametric or non-parametric analysis. Independent Student's t-test or Mann-Whitney test will be used to compare the differences between groups, and Pearson's correlation coefficient or Spearman's correlation coeficiente will be used to correlate the data. (AU)