Immune Sensing and Potential Immunotherapeutic Approaches to Control Chromoblastomycosis

Autor(es)

Breda, Leandro C. D. ^[1] ; Menezes, Isabela G. ^[1] ; Paulo, Larissa N. M. ^[1] ; de Almeida, Sandro Rogerio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF FUNGI; v. 7, n. 1 JAN 2021.
• Citações Web of Science: 0

Resumo

Chromoblastomycosis (CBM) is a neglected, chronic, and progressive subcutaneous mycosis caused by different species of fungi from the Herpotrichiellaceae family. CBM disease is usually associated with agricultural activities, and its infection is characterized by verrucous, erythematous papules, and atrophic lesions on the upper and lower limbs, leading to social stigma and impacts on patients' welfare. The economic aspect of disease treatment is another relevant issue. There is no specific treatment for CBM, and different anti-fungal drug associations are used to treat the patients. However, the long period of the disease and the high cost of the treatment lead to treatment interruption and, consequently, relapse of the disease. In previous years, great progress had been made in the comprehension of the CBM pathophysiology. In this review, we discuss the differences in the cell wall composition of conidia, hyphae, and muriform cells, with a particular focus on the activation of the host immune response. We also highlight the importance of studies about the host skin immunology in CBM. Finally, we explore different immunotherapeutic studies, highlighting the importance of these approaches for future treatment strategies for CBM. (AU)

• Processo FAPESP: 18/11624-9 - Identificação de peptideos imunogênicos de Fonsecaea pedrosoi e sua possivel utilização em processos vacinais na cromoblastomicose experimental
• Beneficiário: Isabela de Godoy Menezes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/18598-7 - Papel de receptores de reconhecimento padrão (PRRs) na ativação de macrófagos nas infecções fúngicas cutâneas causadas por Fonsecaea pedrosoi, Sporothrix schenckii e Trichophyton rubrum
• Beneficiário: Sandro Rogerio de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/14347-9 - Estudo das funções efetoras e do metabolismo de macrófagos e neutrófilos na eliminação do fungo Fonsecaea pedrosoi
• Beneficiário: Leandro Carvalho Dantas Breda
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado