Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study

Autor(es):Mostrar menos -

de Camargo, Adriano Costa ^{[1, 2]} ; de Souza Silva, Anna Paula ^[3] ; Soares, Jackeline Cintra ^[3] ; de Alencar, Severino Matias ^[3] ; Handa, Cintia Ladeira ^[4] ; Cordeiro, Karina Silva ^[5] ; Figueira, Marcela Souza ^[5] ; Sampaio, Geni R. ^[5] ; Torres, Elizabeth A. F. S. ^[5] ; Shahidi, Fereidoon ^[6] ; Schwember, Andres R. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Chile, Nutr & Food Technol Inst, Lab Antioxidants, Santiago 7830490 - Chile

^[2] Pontificia Univ Catolica Chile, Fac Agron & Ingn Forestal, Dept Ciencias Vegetales, Santiago 7830490 - Chile

^[3] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind Food & Nutr, POB 9, BR-13418900 Piracicaba, SP - Brazil

^[4] Minas Gerais State Univ, R Ver Geraldo Moises da Silva 308-434, BR-38302182 Ituiutaba, MG - Brazil

^[5] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, 715 Dr Arnaldo Ave, BR-01246904 Sao Paulo, SP - Brazil

^[6] Mem Univ Newfoundland, Dept Biochem, St John, NF A1B 3X9 - Canada

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 26, n. 2 JAN 2021.
• Citações Web of Science: 0

Resumo

A clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat were evaluated in this contribution. The highest recovery of phenolics was achieved using aqueous acetone (50:50, v/v), as verified by multi-response optimization, thus showing that phenolics could be largely underestimated by employing an inappropriate extraction. The concentration of derivatives of apigenin, the main phenolics present, ranged from 63.5 to 80.7%, as evaluated by LC-ESI-QTOF-MS. Phenolics from the breeding line 98 exhibited the highest ability in scavenging peroxyl radicals, reducing power as well as in terms of inhibition of pancreatic lipase activity, a key enzyme regulating the absorption of triacylglycerols. In contrast, none of the samples exhibited a significant anti-diabetic potential. Despite their high concentration compared to that of phenolic acids, results of this work do not support a significant antioxidant and pancreatic lipase inhibitory effect of durum wheat flavonoids. Therefore, breeding programs and animal and/or human trials related to the effect of durum wheat flavonoids on oxidative stress and absorption of triacylglycerols are discouraged at this point. (AU)

• Processo FAPESP: 17/20039-0 - Efeitos do guaraná (Paullinia cupana) no metabolismo lipídico e bioacessibilidade de seus polifenóis em genes relacionados à absorção de colesterol em células Caco-2
• Beneficiário: Elizabeth Aparecida Ferraz da Silva Torres
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/06514-4 - Composição química e potencial de desativação de espécies reativas de oxigênio de novas cultivares de amendoim adaptadas a ambientes semiáridos: uma contribuição em conjunto com a Embrapa ao desenvolvimento econômico/social do Nordeste brasileiro
• Beneficiário: Severino Matias de Alencar
• Modalidade de apoio: Auxílio à Pesquisa - Regular