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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study

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Author(s):
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de Camargo, Adriano Costa [1, 2] ; de Souza Silva, Anna Paula [3] ; Soares, Jackeline Cintra [3] ; de Alencar, Severino Matias [3] ; Handa, Cintia Ladeira [4] ; Cordeiro, Karina Silva [5] ; Figueira, Marcela Souza [5] ; Sampaio, Geni R. [5] ; Torres, Elizabeth A. F. S. [5] ; Shahidi, Fereidoon [6] ; Schwember, Andres R. [2]
Total Authors: 11
Affiliation:
[1] Univ Chile, Nutr & Food Technol Inst, Lab Antioxidants, Santiago 7830490 - Chile
[2] Pontificia Univ Catolica Chile, Fac Agron & Ingn Forestal, Dept Ciencias Vegetales, Santiago 7830490 - Chile
[3] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind Food & Nutr, POB 9, BR-13418900 Piracicaba, SP - Brazil
[4] Minas Gerais State Univ, R Ver Geraldo Moises da Silva 308-434, BR-38302182 Ituiutaba, MG - Brazil
[5] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, 715 Dr Arnaldo Ave, BR-01246904 Sao Paulo, SP - Brazil
[6] Mem Univ Newfoundland, Dept Biochem, St John, NF A1B 3X9 - Canada
Total Affiliations: 6
Document type: Journal article
Source: Molecules; v. 26, n. 2 JAN 2021.
Web of Science Citations: 0
Abstract

A clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat were evaluated in this contribution. The highest recovery of phenolics was achieved using aqueous acetone (50:50, v/v), as verified by multi-response optimization, thus showing that phenolics could be largely underestimated by employing an inappropriate extraction. The concentration of derivatives of apigenin, the main phenolics present, ranged from 63.5 to 80.7%, as evaluated by LC-ESI-QTOF-MS. Phenolics from the breeding line 98 exhibited the highest ability in scavenging peroxyl radicals, reducing power as well as in terms of inhibition of pancreatic lipase activity, a key enzyme regulating the absorption of triacylglycerols. In contrast, none of the samples exhibited a significant anti-diabetic potential. Despite their high concentration compared to that of phenolic acids, results of this work do not support a significant antioxidant and pancreatic lipase inhibitory effect of durum wheat flavonoids. Therefore, breeding programs and animal and/or human trials related to the effect of durum wheat flavonoids on oxidative stress and absorption of triacylglycerols are discouraged at this point. (AU)

FAPESP's process: 17/20039-0 - Effects of guaraná (Paullinia cupana) on lipid metabolism and bioacessibility of its polyphenols in genes related to the absorption of cholesterol in Caco-2 cells
Grantee:Elizabeth Aparecida Ferraz da Silva Torres
Support Opportunities: Regular Research Grants
FAPESP's process: 16/06514-4 - Chemical composition and scavenging potential of reactive oxygen species form new peanuts cultivars adapted to semiarid environments: a contribution to the economical and social development of Northeast Brazil together with Embrapa
Grantee:Severino Matias de Alencar
Support Opportunities: Regular Research Grants