Epigenetic regulation of retinal development

Autor(es)

Raeisossadati, Reza ^{[1, 2, 3]} ; Ferrari, Merari F. R. ^[1] ; Kihara, Alexandre Hiroaki ^[4] ; AlDiri, Issam ^{[2, 3]} ; Gross, Jeffrey M. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, Rua Do Matao 277, Cidade Univ, BR-05508090 Sao Paulo, SP - Brazil

^[2] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Louis J Fox Ctr Vis Restorat, Pittsburgh, PA 15261 - USA

^[3] Univ Pittsburgh, Sch Med, Dept Dev Biol, Louis J Fox Ctr Vis Restorat, Pittsburgh, PA 15261 - USA

^[4] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Santo Andre, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EPIGENETICS & CHROMATIN; v. 14, n. 1 DEC 9 2021.
• Citações Web of Science: 0

Resumo

In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determination and terminal differentiation are controlled by intricate crosstalk between the genome and epigenome. Indeed, epigenetic regulation plays pivotal roles in numerous cell fate specification and differentiation events in the retina. Moreover, aberrant chromatin structure can contribute to developmental disorders and retinal pathologies. In this review, we highlight recent advances in our understanding of epigenetic regulation in the retina. We also provide insight into several aspects of epigenetic-related regulation that should be investigated in future studies of retinal development and disease. Importantly, focusing on these mechanisms could contribute to the development of novel treatment strategies targeting a variety of retinal disorders. (AU)

• Processo FAPESP: 18/07592-4 - Papel dos mecanismos de controle de qualidade na perda da proteostase em doenças neurodegenerativas dependentes da idade
• Beneficiário: Merari de Fátima Ramires Ferrari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/01290-9 - Análise da interação e dinâmica mitocondrial e do ER durante a agregação proteica
• Beneficiário: Seyed Reza Raeisossadati
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado