Epigenetic regulation of retinal development

Author(s)

Raeisossadati, Reza ^{[1, 2, 3]} ; Ferrari, Merari F. R. ^[1] ; Kihara, Alexandre Hiroaki ^[4] ; AlDiri, Issam ^{[2, 3]} ; Gross, Jeffrey M. ^{[2, 3]}

Affiliation

^[1] Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, Rua Do Matao 277, Cidade Univ, BR-05508090 Sao Paulo, SP - Brazil

^[2] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Louis J Fox Ctr Vis Restorat, Pittsburgh, PA 15261 - USA

^[3] Univ Pittsburgh, Sch Med, Dept Dev Biol, Louis J Fox Ctr Vis Restorat, Pittsburgh, PA 15261 - USA

^[4] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Santo Andre, SP - Brazil

• Document type: Review article
• Source: EPIGENETICS & CHROMATIN; v. 14, n. 1 DEC 9 2021.
• Web of Science Citations: 0

Abstract

In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determination and terminal differentiation are controlled by intricate crosstalk between the genome and epigenome. Indeed, epigenetic regulation plays pivotal roles in numerous cell fate specification and differentiation events in the retina. Moreover, aberrant chromatin structure can contribute to developmental disorders and retinal pathologies. In this review, we highlight recent advances in our understanding of epigenetic regulation in the retina. We also provide insight into several aspects of epigenetic-related regulation that should be investigated in future studies of retinal development and disease. Importantly, focusing on these mechanisms could contribute to the development of novel treatment strategies targeting a variety of retinal disorders. (AU)

• FAPESP's process: 18/07592-4 - The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative diseases
• Grantee: Merari de Fátima Ramires Ferrari
• Support type: Regular Research Grants
• FAPESP's process: 19/01290-9 - Analysis of ER and mitochondria dynamics and interaction during protein aggregation
• Grantee: Seyed Reza Raeisossadati
• Support type: Scholarships in Brazil - Post-Doctorate