| Texto completo | |
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Mansour, Eli
[1]
;
Palma, Andre C.
[1]
;
Ulaf, Raisa G.
[1]
;
Ribeiro, Luciana C.
[1]
;
Bernardes, Ana Flavia
[1]
;
Nunes, Thyago A.
[1]
;
Agrela, V, Marcus
;
Bombassaro, Bruna
[2]
;
Monfort-Pires, Milena
[2]
;
Camargo, Rafael L.
[2]
;
Araujo, Eliana P.
[2, 3]
;
Brunetti, Natalia S.
[4]
;
Farias, Alessandro S.
[4]
;
Falcao, Antonio Luis E.
[5]
;
Santos, Thiago Martins
[6]
;
Trabasso, Plinio
[6]
;
Dertkigil, Rachel P.
[7]
;
Dertkigil, Sergio S.
[7]
;
Moretti, Maria Luiza
[6]
;
Velloso, Licio A.
[6, 2]
Número total de Autores: 20
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Obes & Comorbid Res Ctr, BR-13083864 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Nursing, BR-13083887 Campinas, SP - Brazil
[4] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Autoimmune Res Lab, BR-13083862 Campinas, SP - Brazil
[5] Univ Estadual Campinas, Sch Med Sci, Dept Surg, BR-13083887 Campinas, SP - Brazil
[6] Agrela, Marcus, V, Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13083887 Campinas, SP - Brazil
[7] Univ Estadual Campinas, Sch Med Sci, Dept Radiol, BR-13083887 Campinas, SP - Brazil
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Viruses-Basel; v. 13, n. 2 FEB 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major pathological finding in autopsies explaining O-2 diffusion failure and hypoxemia. Only dexamethasone has been shown to reduce mortality in severe cases, further supporting a role for inflammation in disease severity. SARS-CoV-2 enters cells employing angiotensin-converting enzyme 2 (ACE2) as a receptor, which is highly expressed in lung alveolar cells. ACE2 is one of the components of the cellular machinery that inactivates the potent inflammatory agent bradykinin, and SARS-CoV-2 infection could interfere with the catalytic activity of ACE2, leading to the accumulation of bradykinin. Methods: In this case control study, we tested two pharmacological inhibitors of the kinin-kallikrein system that are currently approved for the treatment of hereditary angioedema, icatibant, and inhibitor of C1 esterase/kallikrein, in a group of 30 patients with severe COVID-19. Results: Neither icatibant nor inhibitor of C1 esterase/kallikrein resulted in changes in time to clinical improvement. However, both compounds were safe and promoted the significant improvement of lung computed tomography scores and increased blood eosinophils, which are indicators of disease recovery. Conclusions: In this small cohort, we found evidence for safety and a beneficial role of pharmacological inhibition of the kinin-kallikrein system in two markers that indicate improved disease recovery. (AU) | |
| Processo FAPESP: | 20/04522-5 - Ensaio clínico de inibição de bradicinina em adultos hospitalizados com COVID-19 grave |
| Beneficiário: | Licio Augusto Velloso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas |
| Beneficiário: | Licio Augusto Velloso |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |