Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children

Autor(es)

Souza, Livia Victorino ^[1] ; de Almeida, Sandro Soares ^[2] ; De Meneck, Franciele ^[1] ; Thomazini, Fernanda ^[3] ; Araujo, Ronaldo Carvalho ^[4] ; Franco do, Maria Carmo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Sch Med, Med Dept, Div Nephrol, Sao Paulo - Brazil

^[2] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Sch Med, Div Translat Med, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Sch Med, Biophys Dept, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Peptides; v. 137, MAR 2021.
• Citações Web of Science: 0

Resumo

Previous reports reveal that +9/-9 polymorphism of the bradykinin B2 receptor (BDKRB2) is suggestive of cardiometabolic diseases. The aim of this study was to examine the impact of BDKRB2 + 9/-9 polymorphism genotypes on the blood pressure parameters and microvascular function in prepubescent children. We screened for BDKRB2 + 9/-9 polymorphism in the DNA of 145 children (86 boys and 59 girls), and its association with body composition, blood pressure levels, biochemical parameters, and endothelial function was determined. No significant association of the BDKRB2 genotypes with gender (P=0.377), race (P=0.949) or family history of cardiovascular disease (CVD) (P=0.858) was observed. Moreover, we did not identify any interaction between BDKRB2 genotypes with a phenotype of obesity (P=0.144). Children carrying the +9/+9 genotype exhibited a significant linear trend with higher levels of systolic blood pressure and pulse pressure (P < 0.001). Moreover, the presence of +9 allele resulted in a decrease of reactive hyperemia index, showing a decreasing linear trend from -9/-9 to +9/+9, wherein this parameter of endothelial function was the lowest in the +9/+9 children, intermediate in the +9/-9 children, and the highest in the -9/-9 children (P< 0.001). There was a significant inverse correlation between reactive hyperemia index and systolic blood pressure (r= - 0.348, P< 0.001) and pulse pressure (r= - 0.399, P< 0.001). Our findings indicate that the +9/+9 BDKRB2 genotype was associated with high blood pressure and microvascular dysfunction in prepubescent Brazilian children. (AU)

• Processo FAPESP: 18/04013-3 - Quantificação da população de micropartículas de origem endotelial circulantes e análise do seu perfil de miRNAs: avaliação do impacto sobre a inter-relação entre o peso ao nascer, níveis pressóricos e função endotelial em crianças de 6 a 12 anos
• Beneficiário: Maria Do Carmo Pinho Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/08361-3 - Avaliação das interações do exercício físico recreativo, peso ao nascer, níveis pressóricos e os componentes do sistema renina-angiotensina-calicreína-cininas em crianças
• Beneficiário: Livia Victorino de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/20082-7 - Sistema calicreína cininas no exercício físico e metabolismo
• Beneficiário: Ronaldo de Carvalho Araújo
• Modalidade de apoio: Auxílio à Pesquisa - Temático