Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity

Autor(es)

Gomes-Santos, Igor L. ^[1] ; Jordao, Camila P. ^[1] ; Passos, Clevia S. ^[1] ; Brum, Patricia C. ^[2] ; Oliveira, Edilamar M. ^[2] ; Chammas, Roger ^[3] ; Camargo, Anamaria A. ^[4] ; Negrao, Carlos E. ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Hosp Clin, Heart Inst InCor, Fac Med, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Hosp Clin, Canc Inst State Sao Paulo ICESP, Fac Med, Sao Paulo - Brazil

^[4] Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN CARDIOVASCULAR MEDICINE; v. 8, APR 1 2021.
• Citações Web of Science: 0

Resumo

Doxorubicin causes cardiotoxicity and exercise intolerance. Pre-conditioning exercise training seems to prevent doxorubicin-induced cardiac damage. However, the effectiveness of the cardioprotective effects of exercise training concomitantly with doxorubicin treatment remains largely unknown. To determine whether low-to-moderate intensity aerobic exercise training during doxorubicin treatment would prevent cardiotoxicity and exercise intolerance, we performed exercise training concomitantly with chronic doxorubicin treatment in mice. Ventricular structure and function were accessed by echocardiography, exercise tolerance by maximal exercise test, and cardiac biology by histological and molecular techniques. Doxorubicin-induced cardiotoxicity, evidenced by impaired ventricular function, cardiac atrophy, and fibrosis. Exercise training did not preserve left ventricular ejection fraction or reduced fibrosis. However, exercise training preserved myocardial circumferential strain alleviated cardiac atrophy and restored cardiomyocyte cross-sectional area. On the other hand, exercise training exacerbated doxorubicin-induced body wasting without affecting survival. Finally, exercise training blunted doxorubicin-induced exercise intolerance. Exercise training performed during doxorubicin-based chemotherapy can be a valuable approach to attenuate cardiotoxicity. (AU)

• Processo FAPESP: 16/21320-1 - Influência do exercício aeróbico sobre a entrega de drogas e resposta à quimioterapia baseada em doxorrubicina em câncer de mama associado à obesidade
• Beneficiário: Igor Lucas Gomes dos Santos
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 15/19076-2 - Efeito do exercício físico na sobrevivência das células tumorais e na formação de tumores
• Beneficiário: Clévia dos Santos Passos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/22814-5 - Câncer e coração: novos paradigmas de diagnóstico e tratamento
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/13690-8 - Papel do exercício físico na prevenção da cardiotoxicidade provocada pelo agente quimioterápico doxorrubicina
• Beneficiário: Igor Lucas Gomes dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado