Fish Oil Diet during Pre-mating, Gestation, and Lactation in Adult Offspring Rats on Cancer Cachexia Prevention

Autor(es)

Oliveira, Sarah Christine Pereira de ^[1] ; Miyaguti, Natalia Angelo da Silva ^[1] ; Russell, Steven Thomas ^[2] ; Tobar, Natalia ^[3] ; Geraldo, Murilo Vieira ^[4] ; Gomes-Marcondes, Maria Cristina Cintra ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Lab Nutr & Canc, Dept Struct & Funct Biol, Inst Biol, Campinas - Brazil

^[2] Aston Univ, Sch Biosci, Coll Hlth & Life Sci, Birmingham, W Midlands - England

^[3] Univ Estadual Campinas, Div Nucl Med, Dept Radiol, Sch Med Sci, Campinas - Brazil

^[4] Univ Estadual Campinas, Canc Cell Biol Lab, Dept Struct & Funct Biol, Inst Biol, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MOLECULAR NUTRITION & FOOD RESEARCH; v. 65, n. 9 APR 2021.
• Citações Web of Science: 0

Resumo

Scope Nutritional supplementation of the maternal diet can modify the cancer susceptibility in adult offspring. Therefore, the authors evaluate the effects of a fish-oil diet administered to a long-term, during pre-mating, gestation, and lactation, in reducing cancer-cachexia damages in adult Walker-256 tumor-bearing offspring. Methods and Results Female rats receive control or fish oil diet during pre-mating, gestation, and lactation. After weaning, male offspring are fed the control diet until adulthood and distributed in (C) control adult-offspring; (W) adult tumor-bearing offspring; (OC) adult-offspring of maternal fish oil diet; (WOC) adult tumor-bearing offspring of maternal fish oil diet groups. Fat body mass is preserved, muscle expression of mechanistic target of rapamicin (mTOR) and eukariotic binding protein of eukariotic factor 4E (4E-BP1) is modified, being associated with lower 20S proteasome protein expression, and the liver alanine aminotransferase (ALT) enzyme content maintained in the WOC group. Also, the OC group shows reduced triglyceridemia. Conclusion In this experimental model of cachexia, the long-term maternal supplementation is a positive strategy to improve liver function and lipid metabolism, as well as to modify muscle proteins expression in the mTOR pathway and also reduce the 20S muscle proteasome protein, without altering the tumor development and muscle wasting in adult tumor-bearing offspring. (AU)

• Processo FAPESP: 17/10809-2 - Avaliação do perfil de Metilação do DNA nos tecidos muscular e tumoral em ratos adultos, portadores do carcinossarcoma de Walker 256, provenientes da prole de ratas submetidas à dieta com óleo de fígado de bacalhau
• Beneficiário: Sarah Christine Pereira de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/11932-5 - Mecanismos Moleculares da prevenção do câncer de ovário: investigação das consequências epigenéticas do uso de contraceptivo oral
• Beneficiário: Sarah Christine Pereira de Oliveira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado
• Processo FAPESP: 19/13937-7 - Nutrição e câncer. estudo dos aspectos moleculares, proteômicos e metabolômicos em modelo experimental de caquexia
• Beneficiário: Natália Miyaguti Angelo da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/02739-4 - Nutrição e câncer: estudo dos aspectos moleculares, proteômicos e metabolômicos em modelo experimental de caquexia
• Beneficiário: Maria Cristina Cintra Gomes Marcondes
• Modalidade de apoio: Auxílio à Pesquisa - Temático