Epidemiology and evolution of Zika virus in Minas Gerais, Southeast Brazil

Autor(es):Mostrar menos -

Iani, Felipe C. M. ^{[1, 2, 3]} ; Giovanetti, Marta ^{[2, 4]} ; Fonseca, Vagner ^{[2, 5, 6]} ; Souza, William M. ^{[1, 7]} ; Adelino, Talita E. R. ^{[2, 3]} ; Xavier, Joilson ^[2] ; Jesus, Jaqueline G. ^{[8, 7]} ; Pereira, Maira A. ^[3] ; Silva, Marcos V. F. ^{[9, 3]} ; Costa, Alana V. B. ^{[9, 3]} ; Silva, Erniria C. ; Mendes, Marcia C. O. ; Filippis, Ana M. B. ^[4] ; Albuquerque, Carlos F. C. ^[10] ; Abreu, Andre L. ^[6] ; Oliveira, Marluce A. A. ^[3] ; Alcantara, Luiz C. J. ^[2] ; Faria, Nuno R. ^{[1, 8, 11]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Oxford, Dept Zool, Oxford - England

^[2] Univ Fed Minas Gerais, Lab Genet Celular & Mol, Belo Horizonte, MG - Brazil

^[3] Fundacao Ezequiel Dias, Lab Cent Saude Publ, Belo Horizonte, MG - Brazil

^[4] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Flavivirus, Rio De Janeiro - Brazil

^[5] Univ KwaZulu Natal, Coll Hlth Sci, KwaZulu Natal Res Innovat & Sequencing Platform K, ZA-4001 Durban - South Africa

^[6] Minist Saude, Secretaria Vigilancia Saude, Lab Saude Publ, Brasilia, DF - Brazil

^[7] Univ Sao Paulo, Fac Med Ribeirao Preto, Ctr Pesquisa Virol, Ribeirao Preto - Brazil

^[8] Univ Sao Paulo, Fac Med, Inst Med Trop, Sao Paulo - Brazil

^[9] Secretaria Estado Saude Minas Gerais, Belo Horizonte, MG - Brazil

^[10] Org Mundial Saude, Org Pan Americana Saude, Brasilia, DF - Brazil

^[11] Imperial Coll London, J IDEA, MRC Ctr Global Infect Dis Anal, London - England

• Tipo de documento: Artigo Científico
• Fonte: INFECTION GENETICS AND EVOLUTION; v. 91, JUL 2021.
• Citações Web of Science: 2

Resumo

Autochthonous Zika virus (ZIKV) transmission in Brazil was first identified in April 2015 in Brazil, with the first ZIKV-associated microcephaly cases detected in October 2015. Despite efforts on understanding ZIKV transmission in Brazil, little is known about the virus epidemiology and genetic diversity in Minas Gerais (MG), the second most populous state in the country. We report molecular and genomic findings from the main public health laboratory in MG. Until January 2020, 26,817 ZIKV suspected infections and 86 congenital syndrome cases were reported in MG state. We tested 8552 ZIKV and microcephaly suspected cases. Ten genomes were generated on-site directly from clinical samples. A total of 1723 confirmed cases were detected in Minas Gerais, with two main epidemic waves; the first and larger epidemic wave peaked in March 2016, with the second smaller wave that peaked in March 2017. Dated molecular clock analysis revealed that multiple introductions occurred in Minas Gerais between 2014 and 2015, suggesting that the virus was circulating unnoticed for at least 16 months before the first confirmed laboratory case that we retrospectively identified in December 2015. Our findings highlight the importance of continued genomic surveillance strategies combined with traditional epidemiology to assist public health laboratories in monitoring and understanding the diversity of circulating arboviruses, which might help attenuate the public health impact of infectious diseases. (AU)

• Processo FAPESP: 18/14389-0 - Centro Conjunto Brasil-Reino Unido para Descoberta, Diagnóstico, Genômica e Epidemiologia de Arbovírus (CADDE)
• Beneficiário: Ester Cerdeira Sabino
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/13981-0 - Caracterização, genômica e diagnóstico de vírus com importância em saúde pública no Brasil por sequenciamento de alto desempenho
• Beneficiário: William Marciel de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/17176-8 - Em tempo real, rápida detecção e sequenciamento de arbovírus no Brasil: Zika, Dengue, Chikungunya e Febre Amarela
• Beneficiário: Ingra Morales Claro
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/12000-1 - Modelagem da dispersão espaço-temporal de arbovírus emergentes usando fontes de dados heterogêneas no Estado de São Paulo
• Beneficiário: Jaqueline Goes de Jesus
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/24251-9 - Abordagens multi-ômicas para o estudo da doença por Chikungunya
• Beneficiário: William Marciel de Souza
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado