Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson's Disease Rat Model

Autor(es)

Campos, Ana Carolina P. ^[1] ; Berzuino, Miria B. ^[1] ; Barbosa, Gabriela R. ^[1] ; Freire, Helena M. R. C. ^[1] ; Lopes, Patricia S. ^[1] ; Assis, Danielle V. ^[1] ; Fonoff, Erich T. ^[2] ; Pagano, Rosana L. ^[1]

Afiliação do(s) autor(es)

^[1] Hosp Sirio Libanes, Div Neurosci, BR-01308060 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Med Sch, Dept Neurol, Div Funct Neurosurg, BR-01246903 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CELLS; v. 10, n. 5 MAY 2021.
• Citações Web of Science: 0

Resumo

Persistent pain is a prevalent symptom of Parkinson's disease (PD), which is related to the loss of monoamines and neuroinflammation. Motor cortex stimulation (MCS) inhibits persistent pain by activating the descending analgesic pathways; however, its effectiveness in the control of PD-induced pain remains unclear. Here, we evaluated the analgesic efficacy of MCS together with serotonergic and spinal glial modulation in an experimental PD (ePD) rat model. Wistar rats with unilateral striatal 6-OHDA and MCS were assessed for behavioral immobility and nociceptive responses. The immunoreactivity of dopamine in the substantia nigra and serotonin in the nucleus raphe magnus (NRM) and the neuronal, astrocytic, and microglial activation in the dorsal horn of the spinal cord were evaluated. MCS, without interfering with dopamine loss, reversed ePD-induced immobility and hypernociception. This response was accompanied by an exacerbated increase in serotonin in the NRM and a decrease in neuronal and astrocytic hyperactivation in the spinal cord, without inhibiting ePD-induced microglial hypertrophy and hyperplasia. Taken together, MCS induces analgesia in the ePD model, while restores the descending serotonergic pathway with consequent inhibition of spinal neurons and astrocytes, showing the role of MCS in PD-induced pain control. (AU)

• Processo FAPESP: 14/20209-4 - Envolvimento das células da glia na via analgésica descendente no modelo de lesão nigroestriatal
• Beneficiário: Ana Carolina Pinheiro Campos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 09/50772-4 - Doença de Parkinson e dor: mecanismos envolvidos na neuroplasticidade nociciptiva e no efeito da estimulação do córtex motor em ratos
• Beneficiário: Rosana de Lima Pagano
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/07231-5 - Envolvimento noradrenérgico e serotonérgico nas alterações nociceptivas e motoras observadas em ratos hemiparkinsonianos
• Beneficiário: Ana Carolina Pinheiro Campos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/07232-1 - Entendendo a hiperalgesia mecânica induzida pela lesão nigroestriatal: avaliação do padrão de ativação central
• Beneficiário: Miriã Benatti Berzuino
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica