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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Motor Cortex Stimulation Reversed Hypernociception, Increased Serotonin in Raphe Neurons, and Caused Inhibition of Spinal Astrocytes in a Parkinson's Disease Rat Model

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Author(s):
Campos, Ana Carolina P. [1] ; Berzuino, Miria B. [1] ; Barbosa, Gabriela R. [1] ; Freire, Helena M. R. C. [1] ; Lopes, Patricia S. [1] ; Assis, Danielle V. [1] ; Fonoff, Erich T. [2] ; Pagano, Rosana L. [1]
Total Authors: 8
Affiliation:
[1] Hosp Sirio Libanes, Div Neurosci, BR-01308060 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Med Sch, Dept Neurol, Div Funct Neurosurg, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CELLS; v. 10, n. 5 MAY 2021.
Web of Science Citations: 0
Abstract

Persistent pain is a prevalent symptom of Parkinson's disease (PD), which is related to the loss of monoamines and neuroinflammation. Motor cortex stimulation (MCS) inhibits persistent pain by activating the descending analgesic pathways; however, its effectiveness in the control of PD-induced pain remains unclear. Here, we evaluated the analgesic efficacy of MCS together with serotonergic and spinal glial modulation in an experimental PD (ePD) rat model. Wistar rats with unilateral striatal 6-OHDA and MCS were assessed for behavioral immobility and nociceptive responses. The immunoreactivity of dopamine in the substantia nigra and serotonin in the nucleus raphe magnus (NRM) and the neuronal, astrocytic, and microglial activation in the dorsal horn of the spinal cord were evaluated. MCS, without interfering with dopamine loss, reversed ePD-induced immobility and hypernociception. This response was accompanied by an exacerbated increase in serotonin in the NRM and a decrease in neuronal and astrocytic hyperactivation in the spinal cord, without inhibiting ePD-induced microglial hypertrophy and hyperplasia. Taken together, MCS induces analgesia in the ePD model, while restores the descending serotonergic pathway with consequent inhibition of spinal neurons and astrocytes, showing the role of MCS in PD-induced pain control. (AU)

FAPESP's process: 14/20209-4 - Involvement of glial cells in descending analgesic pathway in model of nigrostriatal lesion
Grantee:Ana Carolina Pinheiro Campos
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/50772-4 - Parkinson disease and pain: mechanisms involved in the nociceptive neuroplasticity and in the effect of motor cortex stimulation in rats
Grantee:Rosana de Lima Pagano
Support Opportunities: Research Grants - Young Investigators Grants