A comprehensive review on the role of protein tyrosine phosphatases in gastric cancer development and progression

Autor(es)

Clerici, Stefano Piatto ^[1] ; de Souza Oliveira, Patricia Fernandes ^[1] ; Akagi, Erica Mie ^[1] ; Cordeiro, Helon Guimaraes ^[1] ; Azevedo-Martins, Jordana Maria ^[1] ; de Sousa Faria, Alessandra Valeria ^[1] ; Ferreira-Halder, Carmen Verissima ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, UNICAMP, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Biological Chemistry; v. 402, n. 6, p. 663-674, MAY 2021.
• Citações Web of Science: 0

Resumo

The main post-translational reversible modulation of proteins is phosphorylation and dephosphorylation, catalyzed by protein kinases (PKs) and protein phosphatases (PPs) which is crucial for homeostasis. Imbalance in this crosstalk can be related to diseases, including cancer. Plenty of evidence indicates that protein tyrosine phosphatases (PTPs) can act as tumor suppressors and tumor promoters. In gastric cancer (GC), there is a lack of understanding of the molecular aspects behind the tumoral onset and progression. Here we describe several members of the PTP family related to gastric carcinogenesis. We discuss the associated molecular mechanisms which support the down or up modulation of different PTPs. We emphasize the Helicobacter pylori (H. pylori) virulence which is in part associated with the activation of PTP receptors. We also explore the involvement of intracellular redox state in response to H. pylori infection. In addition, some PTP members are under influence by genetic mutations, epigenetics mechanisms, and miRNA modulation. The understanding of multiple aspects of PTPs in GC may provide new targets and perspectives on drug development. (AU)

• Processo FAPESP: 17/08119-8 - Primeira etapa da disseminação hematogênica de células de câncer de cólon retal: influência da LMWPTP e do 3-bromopiruvato
• Beneficiário: Alessandra Valéria de Sousa Faria
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/16625-0 - Importância da proteína tirosina fosfatase de baixo peso molecular na reprogramação do metabolismo tumoral
• Beneficiário: Erica Mie Akagi da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/20412-7 - Proteína tirosina fosfatase de baixo peso molecular em câncer de cólon retal: da bancada à geração de produto
• Beneficiário: Carmen Veríssima Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/03593-6 - Educação plaquetária e metástase: relevância da LMWPTP e vesículas extracelulares no Câncer Colorretal
• Beneficiário: Stefano Piatto Clerici
• Modalidade de apoio: Bolsas no Brasil - Doutorado