A comprehensive review on the role of protein tyrosine phosphatases in gastric cancer development and progression

Author(s)

Clerici, Stefano Piatto ^[1] ; de Souza Oliveira, Patricia Fernandes ^[1] ; Akagi, Erica Mie ^[1] ; Cordeiro, Helon Guimaraes ^[1] ; Azevedo-Martins, Jordana Maria ^[1] ; de Sousa Faria, Alessandra Valeria ^[1] ; Ferreira-Halder, Carmen Verissima ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, UNICAMP, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil

• Document type: Review article
• Source: Biological Chemistry; v. 402, n. 6, p. 663-674, MAY 2021.
• Web of Science Citations: 0

Abstract

The main post-translational reversible modulation of proteins is phosphorylation and dephosphorylation, catalyzed by protein kinases (PKs) and protein phosphatases (PPs) which is crucial for homeostasis. Imbalance in this crosstalk can be related to diseases, including cancer. Plenty of evidence indicates that protein tyrosine phosphatases (PTPs) can act as tumor suppressors and tumor promoters. In gastric cancer (GC), there is a lack of understanding of the molecular aspects behind the tumoral onset and progression. Here we describe several members of the PTP family related to gastric carcinogenesis. We discuss the associated molecular mechanisms which support the down or up modulation of different PTPs. We emphasize the Helicobacter pylori (H. pylori) virulence which is in part associated with the activation of PTP receptors. We also explore the involvement of intracellular redox state in response to H. pylori infection. In addition, some PTP members are under influence by genetic mutations, epigenetics mechanisms, and miRNA modulation. The understanding of multiple aspects of PTPs in GC may provide new targets and perspectives on drug development. (AU)

• FAPESP's process: 17/08119-8 - Hematogenous tumor metastasis in colon rectal cancer cells: influence of LMWPTP and 3-bromopyruvate
• Grantee: Alessandra Valéria de Sousa Faria
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/16625-0 - Importance of the low molecular weight protein tyrosine phosphatase in the tumoral metabolism reprogramming
• Grantee: Erica Mie Akagi da Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/20412-7 - Low molecular weight protein tyrosine phosphatase in colorectal cancer: from the bench to product generation
• Grantee: Carmen Veríssima Ferreira
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/03593-6 - Tumor-educated platelets and metastasis: relevance of LMWPTP and extracellular vesicles in Colorectal Cancer
• Grantee: Stefano Piatto Clerici
• Support Opportunities: Scholarships in Brazil - Doctorate