| Texto completo | |
| Autor(es): Mostrar menos - |
Reis, Fernando Mcv
[1]
;
Lee, Johannes Y.
[2]
;
Maesta-Pereira, Sandra
[1]
;
Schuette, Peter J.
[1]
;
Chakerian, Meghmik
[1]
;
Liu, Jinhan
[2]
;
La-Vu, Mimi Q.
[1]
;
Tobias, Brooke C.
[1]
;
Ikebara, Juliane M.
[3]
;
Kihara, Alexandre Hiroaki
[3]
;
Canteras, Newton S.
[4]
;
Kao, Jonathan C.
[2]
;
Adhikari, Avishek
[1]
Número total de Autores: 13
|
| Afiliação do(s) autor(es): | [1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA
[2] Univ Calif Los Angeles, Dept Elect & Comp Engn, Los Angeles, CA 90095 - USA
[3] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Sao Bernardo Do Campo, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | eLIFE; v. 10, MAY 6 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance. We identified a dPAG threatavoidance ensemble in mice that showed higher activity farther from threats such as the open arms of the elevated plus maze and a predator. These cells were also more active during threat avoidance behaviors such as escape and freezing, even though these behaviors have antagonistic motor output. Conversely, the threat approach ensemble was more active during risk assessment behaviors and near threats. Furthermore, unsupervised methods showed that avoidance/approach states were encoded with shared activity patterns across threats. Lastly, the relative number of cells in each ensemble predicted threat avoidance across mice. Thus, dPAG ensembles dynamically encode threat approach and avoidance states, providing a flexible mechanism to balance risk assessment and danger avoidance. (AU) | |
| Processo FAPESP: | 17/08668-1 - Estudo in vivo de populações neuronais GABAérgicas e glutamatérgicas da substância cinzenta periaquedutal em resposta a diferentes tipos de ameaça |
| Beneficiário: | Fernando Midea Cuccovia Vasconcelos Reis |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |
| Processo FAPESP: | 14/05432-9 - Bases neurais do medo e agressão |
| Beneficiário: | Newton Sabino Canteras |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/17677-0 - Efeitos da anóxia neonatal na memória espacial e atividade das células de lugar em roedores adultos |
| Beneficiário: | Juliane Midori Ikebara |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |