| Full text | |
| Author(s): Show less - |
Reis, Fernando Mcv
[1]
;
Lee, Johannes Y.
[2]
;
Maesta-Pereira, Sandra
[1]
;
Schuette, Peter J.
[1]
;
Chakerian, Meghmik
[1]
;
Liu, Jinhan
[2]
;
La-Vu, Mimi Q.
[1]
;
Tobias, Brooke C.
[1]
;
Ikebara, Juliane M.
[3]
;
Kihara, Alexandre Hiroaki
[3]
;
Canteras, Newton S.
[4]
;
Kao, Jonathan C.
[2]
;
Adhikari, Avishek
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA
[2] Univ Calif Los Angeles, Dept Elect & Comp Engn, Los Angeles, CA 90095 - USA
[3] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Sao Bernardo Do Campo, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | eLIFE; v. 10, MAY 6 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance. We identified a dPAG threatavoidance ensemble in mice that showed higher activity farther from threats such as the open arms of the elevated plus maze and a predator. These cells were also more active during threat avoidance behaviors such as escape and freezing, even though these behaviors have antagonistic motor output. Conversely, the threat approach ensemble was more active during risk assessment behaviors and near threats. Furthermore, unsupervised methods showed that avoidance/approach states were encoded with shared activity patterns across threats. Lastly, the relative number of cells in each ensemble predicted threat avoidance across mice. Thus, dPAG ensembles dynamically encode threat approach and avoidance states, providing a flexible mechanism to balance risk assessment and danger avoidance. (AU) | |
| FAPESP's process: | 17/08668-1 - In vivo study of GABAergic and glutamatergic neuronal populations of the periaqueductal gray matter in response to different kinds of threat |
| Grantee: | Fernando Midea Cuccovia Vasconcelos Reis |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 14/05432-9 - Neural bases of fear and aggression |
| Grantee: | Newton Sabino Canteras |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/17677-0 - Effects of neonatal anoxia on spatial memory and place cells activity in adult rodents |
| Grantee: | Juliane Midori Ikebara |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |