Metabolomic and secretomic approach to the resistance features of the fungus Aspergillus niger IOC 4687 to copper stress

Autor(es)

Cota de Almeida, Silas Perdigao ^[1] ; Rozas, Enrique Eduardo ^[1] ; Oller do Nascimento, Claudio Augusto ^[1] ; Dias, Meriellen ^[1] ; Mendes, Maria Anita ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dempster MS Lab, Chem Engn Dept, Polytech Sch, Rua Lago 250, Bloco B 3 Andar, BR-05508080 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: METALLOMICS; v. 13, n. 1 JAN 2021.
• Citações Web of Science: 0

Resumo

Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features of resistance of this strain to copper stress. To investigate the metabolites produced under oxidative stress conditions, gas chromatography-mass spectrometry analysis was performed. The secretome principal component analysis results showed that mannitol could be the main metabolite responsible for conferring resistance to the fungus, and gluconic acid is the possible cause of copper desorption because of its chelating ability. The meta-analysis of the metabolome of A. niger IOC 4687 indicated that a low concentration of sorbitol and ribonolactone during growth may be an indicator of oxidative stress. (AU)

• Processo FAPESP: 13/50218-2 - CEPEMA - Centro Cooperativo em Engenharia Ambiental
• Beneficiário: Claudio Augusto Oller do Nascimento
• Modalidade de apoio: Auxílio à Pesquisa - Temático