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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Metabolomic and secretomic approach to the resistance features of the fungus Aspergillus niger IOC 4687 to copper stress

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Author(s):
Cota de Almeida, Silas Perdigao [1] ; Rozas, Enrique Eduardo [1] ; Oller do Nascimento, Claudio Augusto [1] ; Dias, Meriellen [1] ; Mendes, Maria Anita [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dempster MS Lab, Chem Engn Dept, Polytech Sch, Rua Lago 250, Bloco B 3 Andar, BR-05508080 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: METALLOMICS; v. 13, n. 1 JAN 2021.
Web of Science Citations: 0
Abstract

Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features of resistance of this strain to copper stress. To investigate the metabolites produced under oxidative stress conditions, gas chromatography-mass spectrometry analysis was performed. The secretome principal component analysis results showed that mannitol could be the main metabolite responsible for conferring resistance to the fungus, and gluconic acid is the possible cause of copper desorption because of its chelating ability. The meta-analysis of the metabolome of A. niger IOC 4687 indicated that a low concentration of sorbitol and ribonolactone during growth may be an indicator of oxidative stress. (AU)

FAPESP's process: 13/50218-2 - CEPEMA - Cooperative Center of Environmental Engineering
Grantee:Claudio Augusto Oller do Nascimento
Support Opportunities: Research Projects - Thematic Grants