A Two Hour Synthesis of the Anti-Parkinson Drug Safinamide Methanesulfonate

Autor(es)

Higa, Vanessa M. ^[1] ; Omori, Alvaro T. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Synlett; v. 32, n. 14 JUN 2021.
• Citações Web of Science: 0

Resumo

The critical moment of the COVID-19 outbreak requires a real-time supply of therapeutic agents. Thus, time economy in the synthesis of biologically active compounds has become increasingly decisive. In this work, we developed a two hour synthesis of the anti-Parkinson drug safinamide methanesulfonate in four steps with a 64% overall yield. Microwave irradiation was used in the first three steps in a one-pot fashion. In fact, the protocol can provide safinamide free base in one hour without a chromatographic purification step. Also, green solvents such as methanol and ethyl acetate are used. (AU)

• Processo FAPESP: 17/18007-2 - EXPANDINDO O USO DA CENOURA (Daucus carota) EM SÍNTESE ORGÂNICA - APLICAÇÕES EM SÍNTESE TOTAL DE MOLÉCULAS BIOATIVAS, NOVOS SUBSTRATOS E DESENVOLVIMENTO DE UMA METODOLOGIA VISANDO O SCALE-UP
• Beneficiário: Alvaro Takeo Omori
• Modalidade de apoio: Auxílio à Pesquisa - Regular