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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Two Hour Synthesis of the Anti-Parkinson Drug Safinamide Methanesulfonate

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Author(s):
Higa, Vanessa M. [1] ; Omori, Alvaro T. [1]
Total Authors: 2
Affiliation:
[1] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Synlett; v. 32, n. 14 JUN 2021.
Web of Science Citations: 0
Abstract

The critical moment of the COVID-19 outbreak requires a real-time supply of therapeutic agents. Thus, time economy in the synthesis of biologically active compounds has become increasingly decisive. In this work, we developed a two hour synthesis of the anti-Parkinson drug safinamide methanesulfonate in four steps with a 64% overall yield. Microwave irradiation was used in the first three steps in a one-pot fashion. In fact, the protocol can provide safinamide free base in one hour without a chromatographic purification step. Also, green solvents such as methanol and ethyl acetate are used. (AU)

FAPESP's process: 17/18007-2 - EXPANDING THE USE OF CARROT BITS (Daucus carota) IN ORGANIC SYNTHESIS - APPLICATIONS IN TOTAL SYNTHESIS OF BIOACTIVE MOLECULES, NOVEL SUBSTRATES AND THE DEVELOPMENT OF A SCALE-UP METHODOLOGY
Grantee:Alvaro Takeo Omori
Support Opportunities: Regular Research Grants