| Texto completo | |
| Autor(es): |
Batista, Andrea N. L.
[1]
;
Angrisani, Bianca R. P.
[1]
;
Lima, Maria Emanuelle D.
[1]
;
da Silva, Stephanie M. P.
[1]
;
Schettini, Vitoria H.
[1]
;
Chagas, Higor A.
[1]
;
dos Santos, Jr., Fernando M.
[1]
;
Batista, Jr., Joao M.
[2]
;
Valverde, Alessandra L.
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Outeiro Sao Joao Batista S-N, BR-24020141 Niteroi, RJ - Brazil
[2] Univ Fed Sao Paulo, Inst Ciencia & Tecnol, Dept Ciencia & Technol, Rua Talim 330, BR-12231280 Sao Jose Dos Campos, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 32, n. 8, p. 1499-1518, AUG 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
The assignment of absolute configuration (AC) is a crucial step in the structural characterization of natural products, especially for those subjected to biological assays. Methods such as X-ray crystallography, stereocontrolled organic synthesis, nuclear magnetic resonance (NMR), and chiroptical spectroscopies are commonly used to determine the AC of chiral natural compounds. Even with these well-established techniques, however, unambiguous stereochemical assignments of natural products remain a challenge, resulting in an increasing number of structural misassignments being reported every year. Herein, we will present the main techniques that have been used in AC reassignments of natural products over the last 10 years, along with some selected examples. Special attention will be paid to the strengths and weaknesses of each approach. With this, we expect to provide the readers with critical information to help them to choose the appropriate methods for correct AC determinations. (AU) | |
| Processo FAPESP: | 19/22319-5 - Marcadores espectrais de dicroísmo circular vibracional: facilitando o assinalamento da configuração absoluta de produtos naturais |
| Beneficiário: | João Marcos Batista Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |