icochalcone A-loaded solid lipid nanoparticles improve antischistosomal activity in vitro and in viv

Autor(es):Mostrar menos -

Silva, Livia Mara ^[1] ; Marconato, Danielle Gomes ^[2] ; Nascimento da Silva, Marcos Paulo ^[3] ; Barbosa Raposo, Nadia Rezende ^[1] ; Silva Facchini, Gabriela de Faria ^[4] ; Macedo, Gilson Costa ^[4] ; Teixeiras, Fernanda de Sa ^[5] ; Barbosa da Silveira Salvadori, Maria Cecilia ^[5] ; Pinto, Priscila de Faria ^[2] ; de Moraes, Josue ^[3] ; Pittella, Frederico ^[1] ; Da Silva Filho, Ademar Alves ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Juiz de Fora, Fac Pharm, Dept Pharmaceut Sci, BR-36036900 Juiz De Fora, MG - Brazil

^[2] Univ Fed Juiz de Fora, Biol Sci Inst, Dept Biochem, BR-36036900 Juiz De Fora, MG - Brazil

^[3] Univ Guarulhos, Res Ctr Neglected Dis, BR-07025000 Guarulhos, SP - Brazil

^[4] Univ Fed Juiz de Fora, Biol Sci Inst, Dept Parasitol Microbiol & Immunol, BR-36036900 Juiz De Fora, MG - Brazil

^[5] Univ Sao Paulo, Inst Fis, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Nanomedicine; v. 16, n. 19 JUL 2021.
• Citações Web of Science: 1

Resumo

Aim: To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid nanoparticles (L-SLNs) and evaluate the L-SLNs in vitro and in vivo against Schistosoma mansoni. Materials \& methods: LicoA was obtained by chromatographic fractionation and encapsulated in SLNs by a modified high shear homogenization method. Results: L-SLNs showed high encapsulation efficiency, with satisfactory particle size, polydispersity index and Zeta potential. Transmission electron microscopy revealed that L-SLNs were rounded and homogenously distributed. Toxicity studies revealed that SLNs decreased the hemolytic and cytotoxic properties of LicoA. Treatment with L-SLNs showed in vivo efficacy against S. mansoni. Conclusion: L-SLNs are efficient in reducing worm burden and SLNs may be a promising delivery system for LicoA to treat S. mansoni infections. (AU)

• Processo FAPESP: 16/22488-3 - Reposicionamento de fármacos para doenças negligenciadas: identificação de novos agentes anti-helmínticos
• Beneficiário: Josué de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular