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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

icochalcone A-loaded solid lipid nanoparticles improve antischistosomal activity in vitro and in viv

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Author(s):
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Silva, Livia Mara [1] ; Marconato, Danielle Gomes [2] ; Nascimento da Silva, Marcos Paulo [3] ; Barbosa Raposo, Nadia Rezende [1] ; Silva Facchini, Gabriela de Faria [4] ; Macedo, Gilson Costa [4] ; Teixeiras, Fernanda de Sa [5] ; Barbosa da Silveira Salvadori, Maria Cecilia [5] ; Pinto, Priscila de Faria [2] ; de Moraes, Josue [3] ; Pittella, Frederico [1] ; Da Silva Filho, Ademar Alves [1]
Total Authors: 12
Affiliation:
[1] Univ Fed Juiz de Fora, Fac Pharm, Dept Pharmaceut Sci, BR-36036900 Juiz De Fora, MG - Brazil
[2] Univ Fed Juiz de Fora, Biol Sci Inst, Dept Biochem, BR-36036900 Juiz De Fora, MG - Brazil
[3] Univ Guarulhos, Res Ctr Neglected Dis, BR-07025000 Guarulhos, SP - Brazil
[4] Univ Fed Juiz de Fora, Biol Sci Inst, Dept Parasitol Microbiol & Immunol, BR-36036900 Juiz De Fora, MG - Brazil
[5] Univ Sao Paulo, Inst Fis, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Nanomedicine; v. 16, n. 19 JUL 2021.
Web of Science Citations: 1
Abstract

Aim: To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid nanoparticles (L-SLNs) and evaluate the L-SLNs in vitro and in vivo against Schistosoma mansoni. Materials \& methods: LicoA was obtained by chromatographic fractionation and encapsulated in SLNs by a modified high shear homogenization method. Results: L-SLNs showed high encapsulation efficiency, with satisfactory particle size, polydispersity index and Zeta potential. Transmission electron microscopy revealed that L-SLNs were rounded and homogenously distributed. Toxicity studies revealed that SLNs decreased the hemolytic and cytotoxic properties of LicoA. Treatment with L-SLNs showed in vivo efficacy against S. mansoni. Conclusion: L-SLNs are efficient in reducing worm burden and SLNs may be a promising delivery system for LicoA to treat S. mansoni infections. (AU)

FAPESP's process: 16/22488-3 - Drug repositioning for neglected diseases: identification of novel anthelmintic agents
Grantee:Josué de Moraes
Support Opportunities: Regular Research Grants