Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase

Autor(es)

Watanabe, Ligia M. ^{[1, 2]} ; Hashimoto, Ann C. ^[1] ; Torres, Daniel J. ^{[1, 3]} ; Alfulaij, Naghum ^{[1, 3]} ; Peres, Rafael ^[4] ; Sultana, Razvan ^[4] ; Maunakea, Alika K. ^[4] ; Berry, Marla J. ^[3] ; Seale, Lucia A. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 - USA

^[2] Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Internal Med, Sao Paulo - Brazil

^[3] Univ Hawaii Manoa, Pacific Biosci Res Ctr, Sch Ocean & Earth Sci & Technol, Honolulu, HI 96822 - USA

^[4] Univ Hawaii Manoa, John A Burns Sch Med, Dept Anat Biochem & Physiol, Honolulu, HI 96813 - USA

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Endocrinology; v. 533, AUG 1 2021.
• Citações Web of Science: 1

Resumo

People with obesity are often dyslipidemic and prescribed statins to prevent cardiovascular events. A common side effect of statin use is myopathy. This could potentially be caused by the reduction of selenoproteins that curb oxidative stress, in turn, affecting creatine metabolism. We determined if statins regulate hepatic and muscular selenoprotein expression, oxidative stress and creatine metabolism. Mice lacking selenocysteine lyase (Scly KO), a selenium-provider enzyme for selenoprotein synthesis, were fed a high-fat, Se-supplemented diet and treated with simvastatin. Statin improved creatine metabolism in females and oxidative responses in both sexes. Male Scly KO mice were heavier than females after statin treatment. Hepatic selenoproteins were unaffected by statin and genotype in females. Statin upregulated muscular Gpx1 in females but not males, while Scly loss downregulated muscular Gpx1 in males and Selenon in females. Osgin1 was reduced in statin-treated Scly KO males after AmpliSeq analysis. These results refine our understanding of the sex-dependent role of selenium in statin responses. (AU)

• Processo FAPESP: 18/09478-4 - Efeito da suplementação com selênio em camundongos com hipercolesterolemia em uso de estatinas
• Beneficiário: Lígia Moriguchi Watanabe
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado