Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A Critical Review of Biological Properties, Delivery Systems and Analytical/Bioanalytical Methods for Determination of Bevacizumab

Texto completo
Autor(es):
Di Filippo, Leonardo Delello [1] ; dos Santos, Karen Cristina [1] ; Hanck-Silva, Gilmar [1] ; de Lima, Felipe Tita [1] ; Gremiao, Maria Palmira Daflon [1] ; Chorilli, Marlus [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY; v. 51, n. 5, p. 445-453, JUL 4 2021.
Citações Web of Science: 3
Resumo

Bevacizumab is a chimeric monoclonal human-murine antibody originated from murine monoclonal antibody (muMAb A4.6.1) with the human immunoglobulin IgG1. BVZ binds the extracellular portion of vascular endothelial growth factor receptors (VEGFR), which have tyrosine kinase activity. The mechanism of action of BVZ involves binding to VEGFR, Flt-1 (VEGFR-1) and KDR/Flk-1 (VEGFR-2), inducing homodimerization of two receptor subunits, and, consequently, autophosphorylation of their tyrosine kinase domains located inside the cytoplasm. With the advent of nanostructured systems it is increasingly necessary to look for safe analytical methods, ensuring the reliability of the results obtained by them, becoming essential to ensure the quality of medicines. In this work, the incorporation of bevacizumab in to different drug delivery systems was presented. Moreover, detailed investigation was performed about methods for qualitative and quantitative analyses of bevacizumab, including, biological fluids, and drug delivery systems, were investigated. Most recently high performance liquid chromatography coupled with various detectors, liquid chromatography, mass spectrometry and ELISA were used for this purpose. Thus, this review was performed to evaluate the benefits of bevacizumab carried by nanostructured systems and the analytical methods available for detection and quantification of these drugs. (AU)

Processo FAPESP: 18/18488-3 - Avaliação do potencial de carreadores lipídicos nanostruturados funcionalizados com bevacizumab para veiculação de docetaxel no tratamento de glioblastoma
Beneficiário:Leonardo Delello Di Filippo
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 18/23430-4 - Avaliação do potencial de lipossomas funcionalizados com bevacizumabe ou ácido hialurônico para incorporação de abiraterona no tratamento do câncer de próstata
Beneficiário:Kaio Pini Santos
Linha de fomento: Bolsas no Brasil - Pós-Doutorado