Naturally occurring hypothermia promotes survival in severe anaphylaxis

Autor(es)

Alberca, Ricardo W. ^[1] ; Gomes, Eliane ^[1] ; Moretti, Eduardo H. ^[1] ; Russo, Momtchilo ^[1] ; Steiner, Alexandre A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Immunology Letters; v. 237, p. 27-32, SEP 2021.
• Citações Web of Science: 0

Resumo

Although hypothermia has received substantial attention as an indicator of severity in anaphylaxis, it has been neglected from the perspective of whether it could act as a disease-modifying factor in this condition. Here, the impact of naturally occurring (spontaneous) hypothermia on anaphylaxis was evaluated in a murine model of ovalbumin (OVA)-induced allergy. Nonextreme changes in the ambient temperature (T-a) were used to modulate the magnitude of spontaneous hypothermia. At a T-a of 24 degrees C, challenge with OVA intraperitoneally or intravenously resulted in a rapid, transient fall in body core temperature, which reached its nadir 4-6 degrees C below baseline in 30 min. This hypothermic response was largely attenuated when the mice were kept at a Ta of 34 degrees C. The T-a-dependent attenuation of hypothermia resulted in a survival rate of only 30%, as opposed to survival of 100% in the condition that favored the development of hypothermia. The protective effect of hypothermia did not involve changes in the rate of mast cell degranulation, as assessed by the concentration of mast cell protease-1 in bodily fluids. On the other hand, hypothermia improved oxygenation of the brain and kidneys, as indicated by higher NAD(+)/NADH ratios. Therefore, it is plausible to propose that naturally occurring hypothermia makes organs more resistant to the anaphylactic insult. (AU)

• Processo FAPESP: 20/09399-7 - Desenvolvimento de hipotermia na inflamação sistêmica: a hipótese da hipóxia encefálica.
• Beneficiário: Eduardo Hermogenes Moretti
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/08699-7 - Caracterização das células T foliculares auxiliadoras específicas na sensibilização por Ovoalbumina associada a diferentes adjuvantes
• Beneficiário: Ricardo Wesley Alberca Custódio
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 13/24694-1 - Imunoterapia na asma experimental por agonistas de receptores toll-like, infecção ou tolerância
• Beneficiário: Momtchilo Russo
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/03418-0 - Hipotermia na Sepse: causas e consequências
• Beneficiário: Alexandre Alarcon Steiner
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/16602-8 - Imunoterapia na asma experimental por CpG
• Beneficiário: Ricardo Wesley Alberca Custódio
• Modalidade de apoio: Bolsas no Brasil - Doutorado