Both Prelimbic and Infralimbic Noradrenergic Neurotransmissions Modulate Cardiovascular Responses to Restraint Stress in Rats

Autor(es)

Oliveira, Leandro A. ^{[1, 2]} ; Pollo, Taciana R. S. ^[1] ; Rosa, Elineia A. ^[1] ; Duarte, Josiane O. ^{[1, 2]} ; Xavier, Carlos H. ^[3] ; Crestani, Carlos C. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Lab Pharmacol, Araraquara, SP - Brazil

^[2] Joint Fed Univ Sao Carlos UFSCar Sao Paulo State, Grad Program Physiol Sci, Sao Carlos, SP - Brazil

^[3] Univ Fed Goias, Inst Biol Sci, Goiania, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHYSIOLOGY; v. 12, AUG 12 2021.
• Citações Web of Science: 0

Resumo

The prelimbic (PL) and infralimbic (IL) subareas of the medial prefrontal cortex (mPFC) have been implicated in physiological and behavioral responses during aversive threats. The previous studies reported the noradrenaline release within the mPFC during stressful events, and the lesions of catecholaminergic terminals in this cortical structure affected stress-evoked local neuronal activation. Nevertheless, the role of mPFC adrenoceptors on cardiovascular responses during emotional stress is unknown. Thus, we investigated the role of adrenoceptors present within the PL and IL on the increase in both arterial pressure and heart rate (HR) and on the sympathetically mediated cutaneous vasoconstriction evoked by acute restraint stress. For this, bilateral guide cannulas were implanted into either the PL or IL of male rats. All animals were also subjected to catheter implantation into the femoral artery for cardiovascular recording. The increase in both arterial pressure and HR and the decrease in the tail skin temperature as an indirect measurement of sympathetically mediated cutaneous vasoconstriction were recorded during the restraint session. We observed that the microinjection of the selective alpha(2)-adrenoceptor antagonist RX821002 into either the PL or IL decreased the pressor response during restraint stress. Treatment of the PL or IL with either the alpha(1)-adrenoceptor antagonist WB4101 or the alpha(2)-adrenoceptor antagonist reduced the restraint-evoked tachycardia. The drop in the tail skin temperature was decreased by PL treatment with the beta-adrenoceptor antagonist propranolol and with the alpha(1)- or alpha(2)-adrenoceptor antagonists. The alpha(2)-adrenoceptor antagonist into the IL also decreased the skin temperature response. Our results suggest that the noradrenergic neurotransmission in both PL and IL mediates the cardiovascular responses to aversive threats. (AU)

• Processo FAPESP: 19/24478-3 - Estudo da participação do córtex insular no controle das respostas cardiovasculares e ansiogênica ao estresse em ratos: avaliação da topografia funcional e do envolvimento da neurotransmissão do fator de liberação de corticotrofina (CRF)
• Beneficiário: Carlos Cesar Crestani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/14376-0 - Comparação do efeito de dois protocolos de estresse crônico sobre a função cardiovascular e autonômica em ratos
• Beneficiário: Carlos Cesar Crestani
• Modalidade de apoio: Auxílio à Pesquisa - Regular