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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Both Prelimbic and Infralimbic Noradrenergic Neurotransmissions Modulate Cardiovascular Responses to Restraint Stress in Rats

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Author(s):
Oliveira, Leandro A. [1, 2] ; Pollo, Taciana R. S. [1] ; Rosa, Elineia A. [1] ; Duarte, Josiane O. [1, 2] ; Xavier, Carlos H. [3] ; Crestani, Carlos C. [1, 2]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Lab Pharmacol, Araraquara, SP - Brazil
[2] Joint Fed Univ Sao Carlos UFSCar Sao Paulo State, Grad Program Physiol Sci, Sao Carlos, SP - Brazil
[3] Univ Fed Goias, Inst Biol Sci, Goiania, Go - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, AUG 12 2021.
Web of Science Citations: 0
Abstract

The prelimbic (PL) and infralimbic (IL) subareas of the medial prefrontal cortex (mPFC) have been implicated in physiological and behavioral responses during aversive threats. The previous studies reported the noradrenaline release within the mPFC during stressful events, and the lesions of catecholaminergic terminals in this cortical structure affected stress-evoked local neuronal activation. Nevertheless, the role of mPFC adrenoceptors on cardiovascular responses during emotional stress is unknown. Thus, we investigated the role of adrenoceptors present within the PL and IL on the increase in both arterial pressure and heart rate (HR) and on the sympathetically mediated cutaneous vasoconstriction evoked by acute restraint stress. For this, bilateral guide cannulas were implanted into either the PL or IL of male rats. All animals were also subjected to catheter implantation into the femoral artery for cardiovascular recording. The increase in both arterial pressure and HR and the decrease in the tail skin temperature as an indirect measurement of sympathetically mediated cutaneous vasoconstriction were recorded during the restraint session. We observed that the microinjection of the selective alpha(2)-adrenoceptor antagonist RX821002 into either the PL or IL decreased the pressor response during restraint stress. Treatment of the PL or IL with either the alpha(1)-adrenoceptor antagonist WB4101 or the alpha(2)-adrenoceptor antagonist reduced the restraint-evoked tachycardia. The drop in the tail skin temperature was decreased by PL treatment with the beta-adrenoceptor antagonist propranolol and with the alpha(1)- or alpha(2)-adrenoceptor antagonists. The alpha(2)-adrenoceptor antagonist into the IL also decreased the skin temperature response. Our results suggest that the noradrenergic neurotransmission in both PL and IL mediates the cardiovascular responses to aversive threats. (AU)

FAPESP's process: 19/24478-3 - Role of the insular cortex in control of the cardiovascular and anxiogenic responses to stress in rats: evaluation of functional topography and involvement of corticotropin-releasing factor (CRF) neurotransmission
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants
FAPESP's process: 12/14376-0 - Comparison of the effect of two protocols of chronic stress in cardiovascular and autonomic functions in rats
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants