Grant number: |
09/05308-8
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Support type: | Scholarships in Brazil - Post-Doctorate |
Effective date (Start): |
January 01, 2010
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Effective date (End): |
February 28, 2014
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Field of knowledge: | Biological Sciences
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Pharmacology
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Neuropsychopharmacology |
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Principal Investigator: | Fernando Morgan de Aguiar Correa |
Grantee: | Cristiane Busnardo Santiago |
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Home Institution: |
Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
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Associated research grant: | 12/17626-7 - Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders,
AP.TEM
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Associated scholarship(s): | 12/09425-1 - Study of the involvement of the nitric oxide-guanylate cyclase mechanism in the paraventricular nucleus of hypothalamus on local neuronal activation and hypothalamic-pituitary-adrenal stimulation induced by restraint stress in rats,
BE.EP.PD
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Abstract
The paraventricular nucleus of the hypothalamus (PVN) has been implicated in several aspects of central cardiovascular control. The PVN has neural connections with several limbic structures involved with both autonomic and behavioral control during defensive situations. It has been reported that the PVN has a dissociated role on cardiovascular responses observed during acute restraint stress (AR). The PVN neurotransmission inhibition is characterized by reduction of the blood pressure increases without effect on tachycardiac response. The AR is an unavoidable stressor that causes mean arterial pressure increase and an intense tachycardiac response, with concomitant increase in the plasma concentrations of corticosterone and adrenocorticotrophin. Moreover, the stressful situations cause a reduction in temperature of the tail skin in rats. This decrease in temperature is due to skin vasoconstriction, and it is, together with cardiovascular alteration, an indicative of autonomic activity. Among the several neurotransmitters present in the PVN which have been reported to participate in cardiovascular modulation, attention has been called upon the glutamatergic and nitrergic systems. Therefore, the hypothesis of the present project is that an interaction between glutamatergic and nitrergic systems present in the PVN are involved with mediation of autonomic and hormonal changes caused by the exposure of rats to AR. To achieve this purpose we will study these neurotransmissions interaction on cardiovascular, temperature and hormonal effects induced by exposure to AR, by local PVN inhibition of both glutamatergic receptor and nitrergic system made before exposing animals to the stress.
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Scientific publications
(7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUSNARDO, CRISTIANE;
CRESTANI, CARLOS C.;
SCOPINHO, AMERICA A.;
PACKARD, BENJAMIN A.;
RESSTEL, LEONARDO B. M.;
CORREA, FERNANDO M. A.;
HERMAN, JAMES P.
Nitrergic neurotransmission in the paraventricular nucleus of the hypothalamus modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,
v. 90,
p. 16-27,
MAR 2 2019.
Web of Science Citations: 4.
BUSNARDO, CRISTIANE;
ALVES, FERNANDO H. F.;
CRESTANI, CARLOS C.;
SCOPINHO, AMERICA A.;
RESSTEL, LEONARDO B. M.;
CORREA, FERNANDO M. A.
Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats.
European Neuropsychopharmacology,
v. 23,
n. 11,
p. 1611-1622,
NOV 2013.
Web of Science Citations: 26.
SANTINI, CIBELE O.;
FASSINI, ALINE;
SCOPINHO, AMERICA A.;
BUSNARDO, CRISTIANE;
CORREA, FERNANDO M. A.;
RESSTEL, LEONARDO B. M.
The ventral hippocampus NMDA receptor/nitric oxide/guanylate cyclase pathway modulates cardiovascular responses in rats.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL,
v. 177,
n. 2,
p. 244-252,
OCT 2013.
Web of Science Citations: 9.
BUSNARDO, CRISTIANE;
CRESTANI, CARLOS C.;
RESSTEL, LEONARDO B. M.;
TAVARES, RODRIGO F.;
ANTUNES-RODRIGUES, JOSE;
CORREA, FERNANDO M. A.
Ionotropic Glutamate Receptors in Hypothalamic Paraventricular and Supraoptic Nuclei Mediate Vasopressin and Oxytocin Release in Unanesthetized Rats.
Endocrinology,
v. 153,
n. 5,
p. 2323-2331,
MAY 2012.
Web of Science Citations: 5.
ALVES, FERNANDO H. F.;
CRESTANI, CARLOS C.;
BUSNARDO, CRISTIANE;
ANTUNES-RODRIGUES, JOSE;
GOMES, FELIPE V.;
RESSTEL, LEONARDO B. M.;
CORREA, FERNANDO M. A.
Hypothalamic supraoptic but not paraventricular nucleus is involved in cardiovascular responses to carbachol microinjected into the bed nucleus of stria terminalis of unanesthetized rats.
Brain Research,
v. 1393,
p. 31-43,
JUN 1 2011.
Web of Science Citations: 6.