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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats

Full text
Author(s):
Busnardo, Cristiane [1] ; Alves, Fernando H. F. [1] ; Crestani, Carlos C. [2] ; Scopinho, America A. [1] ; Resstel, Leonardo B. M. [1] ; Correa, Fernando M. A. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, BR-01049010 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: European Neuropsychopharmacology; v. 23, n. 11, p. 1611-1622, NOV 2013.
Web of Science Citations: 26
Abstract

In the present study, the involvement of paraventricular nucleus of the hypothalamus (PVN) glutamate receptors in the modulation of autonomic (arterial blood pressure, heart rate and tail skin temperature) and neuroendocrine (plasma corticosterone) responses and behavioral consequences evoked by the acute restraint stress in rats was investigated. The bilateral microinjection of the selective non-NMDA glutamate receptor antagonist NBQX (2 nmol/ 100 nL) into the PVN reduced the arterial pressure increase as well as the fall in the tail cutaneous temperature induced by the restraint stress, without affecting the stress-induced tachycardiac response. On the other hand, the pretreatment of the PVN with the selective NMDA glutamate receptor antagonist LY235959 (2 nmol/ 100 nL) was able to increase the stress-evoked pressor and tachycardiac response, without affecting the fall in the cutaneous tail temperature. The treatment of the PVN with LY235959 also reduced the increase in plasma corticosterone levels during stress and inhibited the anxiogenic-like effect observed in the elevated plus-maze 24 h after the restraint session. The present results show that NMDA and non-NMDA receptors in the PVN differently modulate responses associated to stress. The PVN glutamate neurotransmission, via non-NMDA receptors, has a facilitatory influence on stress-evoked autonomic responses. On the other hand, the present data point to an inhibitory role of PVN NMDA receptors on the cardiovascular responses to stress. Moreover, our findings also indicate an involvement of PVN NMDA glutamate receptors in the mediation of the plasma corticosterone response as well as in the delayed emotional consequences induced by the restraint stress. (C) 2012 Elsevier B.V. and ECNR All rights reserved. (AU)

FAPESP's process: 09/05308-8 - Role of the hypothalamus paraventricular nucleus on cardiovascular and neuroendocrine responses observed during acute restraint stress in rats
Grantee:Cristiane Busnardo Santiago
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 10/09462-9 - Study of peripheral mechanisms involved in the cardiovascular response during sepsis in rats: possible involvement of the endocannabinoid system
Grantee:Fernando Henrique Ferrari Alves
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 10/16192-8 - Cardiovascular effects of chronic administration of cocaine and testosterone in rats
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants