| Texto completo | |
| Autor(es): |
Marqueze, Elaine C.
[1, 2]
;
Nogueira, Luciana F. R.
[2]
;
Vetter, Celine
[3]
;
Skene, Debra J.
[4]
;
Cipolla-Neto, Jose
[5, 6]
;
Moreno, Claudia R. C.
[1, 7]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Publ Hlth, Dept Hlth Life Cycles & Soc, Sao Paulo - Brazil
[2] Univ Catolica Santos, Publ Hlth Grad Program, Dept Epidemiol, Sao Paulo - Brazil
[3] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 - USA
[4] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey - England
[5] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
[6] Abu Dhabi Univ, Coll Hlth Sci, Abu Dhabi - U Arab Emirates
[7] Stockholm Univ, Stress Res Inst, Dept Psychol, Stockholm - Sweden
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Pineal Research; v. 71, n. 2 SEP 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Shift workers experience chronic circadian misalignment, which can manifest itself in reduced melatonin production, and has been associated with metabolic disorders. In addition, chronotype modulates the effect of night shift work, with early types presenting greater circadian misalignment when working night shift as compared to late types. Melatonin supplementation has shown positive results reducing weight gain in animal models, but the effect of exogenous melatonin in humans on body weight in the context of shift work remains inconsistent. The aim of this study was thus to evaluate the effects of exogenous melatonin on circadian misalignment and body weight among overweight night shift workers, according to chronotype, under real-life conditions. We conducted a double-blind, randomized, placebo-controlled, crossover trial where melatonin (3 mg) or placebo was administered on non-night shift nights for 12 weeks in 27 female nurses (37.1 yo, +/- 5.9 yo; BMI 29.9 kg/m(2), +/- 3.3 kg/m(2)). Melatonin (or placebo) was only taken on nights when the participants did not work night shifts, that is, on nights when they slept (between night shifts and on days off). Composite Phase Deviations (CPD) of actigraphy-based mid-sleep timing were calculated to measure circadian misalignment. The analyses were performed for the whole group and by chronotype. We found approximately 20% reduction in circadian misalignment after exogenous melatonin administration considering all chronotypes. Moreover, melatonin supplementation in those who presented high circadian misalignment, as observed in early chronotypes, reduced body weight, BMI, waist circumference, and hip circumference, without any change in the participants' calorie intake or physical activity levels. (AU) | |
| Processo FAPESP: | 14/50457-0 - Melatonina e a regulação do metabolismo energético: estudos básicos, clínicos e epidemiológicos |
| Beneficiário: | José Cipolla Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |